溃疡性结肠炎炎细胞免疫表型及部分组织病理学指标的表达
溃疡性结肠炎,,溃疡性结肠炎；淋巴细胞；巨噬细胞；嗜酸性粒细胞；不典型增生,摘要,关键词,1资料与方法,2结果,3讨论,参考文献
摘要: 目的：研究溃疡性结肠炎(UC)结肠粘膜不同时期浸润的炎细胞的免疫表型及部分组织病理学指标的表达，为UC的诊断提供依据。方法：采用免疫组织化学的方法检测UC活动组(59例)、非活动组(28例)及对照组CD20、CD45RO、CD68的表达，并分析各组的嗜酸性粒细胞和不典型增生的检出情况。结果：UC非活动组、活动组CD20的阳性表达率分别为46%、60%，明显高于对照组(17%)(P<0.05)，CD68阳性表达率分别为54%、82%，与对照组(75%)相比差异均有统计学意义(P<0.05),UC活动组CD45RO阳性表达率为96%,明显高于对照组(83%)(P<0.05)。UC活动组嗜酸性粒细胞检出率为78%,明显高于对照组(50%)(P<0.05)，UC活动组不典型增生检出率与非活动组无明显差异(P>0.05)。结论：细胞免疫和嗜酸性粒细胞的浸润在活动期UC发病中起重要作用；巨噬细胞和体液免疫在UC病程中起重要作用，但不能区分疾病严重程度；腺体的不典型增生与UC活动性间无明显关系。关键词：溃疡性结肠炎；淋巴细胞；巨噬细胞；嗜酸性粒细胞；不典型增生
study on ulcerative colitisCAI Tingting， ZHANG Yongping, LIU Guitao, et al
(Department of Pathology, First Affiliated Hospital, Xinjiang Medical University,
Urumqi 830000, China)Abstract: Objective：To reveal immunocharacteristics of inflamative cells in colonic lamina propria of different period ulcerative colitis (UC) and some tissue pathologic indexes, and provide diagnostic foundation. Methods： To detect the expressions of CD20, CD45RO, CD68 in active (n=59)、inactive (n=28) and controls with immunohistochemistry，and to analyse the statues of eosinophil and atypical hyperplasia. Results：(1)The positive rates of CD20 were both higher in inactive and active ones than in controls (P<0.05),(2)The positive rate of CD45RO was higher in active ones than in controls (P<0.05) ......
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