摘要:目的 探讨派罗欣联合阿德福韦酯治疗慢性乙型肝炎的临床疗效。 方法 将龙川县人民医院2003～2005年慢性乙型肝炎患者48例，随机分为两组，每组24例。治疗组予派罗欣联合阿德福韦酯治疗;对照组予α-干扰素、拉米夫定;疗程24周，治疗后检测乙肝患者ALT、AST、HBeAg、HBVDNA变化。 结果 治疗结束时，两组患者临床症状均有明显改善，两组ALT复常率差异有显著意义，HBVDNA阴转率、HBeAg阴转率有显著统计学差异(P<0.05)。 结论 派罗欣联合阿德福韦酯对乙型肝炎疗效优于α-干扰素联合拉米夫定。

    关键词:乙型肝炎;阿德福韦酯;拉米夫定;派罗欣

    Observation on the effect of Pegasys in combination with adefovir dipivoxil on hepatitis B patients.

    ZENG Wei-qiang.

    (Department of Infectious Diseases of Longchuan County People's Hospital，Longchuan517300，Guangdong，P.R.China)

    Abstract:Objective To explore the clinical effect of pegasys in combination with adeforvir dipivoxil on hepatitis B patients. Methods Forty-eight hepatitis B patients hospitalized in Longchuan County People's Hospital in2003～2005were randomly divid-ed into treatment group and control group each consisted of24cases.The patients in treatment group were treated with pegasys in combination with adeforvir dipivoxil and those in the control group were treated withα-interferon and lamivudine for a course of24weeks.The levels of ALT ......