鼻腔原发性恶性黑色素瘤的诊治
鼻腔；恶性黑色素瘤；活检；手术治疗,,鼻腔；恶性黑色素瘤；活检；手术治疗,【摘要】,【关键词】,1资料与方法,2结果,3讨论,【参考文献】
【摘要】 目的 提高对鼻腔原发性恶性黑色素瘤的诊治水平。方法 对1994年8月～2005年4月间诊治的鼻腔原发性恶性黑色素瘤11例临床资料进行回顾性分析。结果 11例中有2例术前分别被误诊为鼻息肉和低分化鳞癌。1例单纯放疗，1例放弃治疗，9例行手术治疗。其中7例行2次以上手术，最多1例行4次手术。4例术后加用化疗。11例中至今生存4例，生存时间分别为6年、3年、15个月、1年。结论 鼻腔原发性恶性黑色素瘤早期症状不明显，易漏诊，凡鼻腔黏膜查见黑色或紫褐色斑块，应尽早行切除式活检，以期早期诊断。广泛切除是治疗鼻腔原发性恶性黑色素瘤的最有效办法，复发病例仍宜再次手术，扩大切除病变，放疗和化疗可作为补充治疗。【关键词】 鼻腔；恶性黑色素瘤；活检；手术治疗
Diagnosis and treatment of primary nasal malignant melanoma
BAO Hong-qin, REN Ming-zhong, CHEN Xiao-ping,et alDepartment of Otolaryngology, Gongli Hospital, Pudong New Area, Shanghai,200135,China
【Abstract】 Objective To improve the diagnosis and treatment of primary nasal malignant melanoma Methods This article reviewed the clinic data of 11cases of primary nasal malignant melanoma from August 1994 to April 2005Results Among the 11 cases,2 were misdiagnosed as nasal polyps and squamous cell carcinoma of low differentiation 1 was treated with simple radiotherapy,1 refused any treatment and 9 were treated with surgery 7 of all operated cases were treated twice or more The most one received 4 operations 4 among 9 operated cases received chemotherapy postoperatively 4 cases survived for 6 years, 3 years ,15 months and 1 yearConclusion Symptoms of primary nasal malignant melanoma are less obvious in the early stage It is easy to miss diagnosis So to get early diagnosis,resection biopsy should be done when we notice a black or brownish spot on the mucosal of the nasal cavity Extensive excision of malignant melanoma is a principle treatment Recurrent local tumors should also be treated by operation Radiotherapy and chemotherapy may be used as complementary therapy ......
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