白藜芦醇；D半乳糖；脂质过氧化_

白藜芦醇对D半乳糖致衰老小鼠氧化损伤的影响

http://www.100md.com 《中华首席医学网》 2006年第3期

白藜芦醇；D半乳糖；脂质过氧化,,白藜芦醇；D半乳糖；脂质过氧化,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的研究白藜芦醇对D半乳糖所致衰老小鼠氧化损伤的缓解作用。方法用D半乳糖皮下注射制备衰老小鼠模型，同时分别给予不同剂量白藜芦醇(15、30 mg/kg)灌胃,观察其对衰老模型小鼠血清和脑组织抗氧化系统的影响。结果衰老模型小鼠脑组织脂褐质(LF)升高，血清和脑组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSHPx)活性下降，一氧化氮(NO)和丙二醛(MDA)含量增加。分别给予15，30 mg/kg白藜芦醇灌胃后能使衰老模型小鼠脑组织和血清中NO、MDA不同程度下降，SOD及GSHPx活性不同程度升高，脑组织中LF降低。结论白藜芦醇可通过清除氧自由基及抗脂质过氧化而抗衰老。

    关键词：白藜芦醇；D半乳糖；脂质过氧化

    Effect of Resveratrol on Oxidative Damage

    Induced by Dgalactose in Senile Mice

    OUYANG Chanhan, WU Jiliang, ZHEN Min

    (Department of Pharmacology, Xianning College, Xianning Hubei 437100,China)

    ABSTRACT:Objective To investigate the neutralization effect of resveratrol on oxidative damage induced by Dgalactose in aged mice. Methods The senile model mice, were established by subcutaneous injection of 5% Dgalactose at the nape, and adminstrated with resveratrol (15, 30 mg/kg) by oral gavage for 30 d. The lipofuscin (LF) and nitric oxide (NO) contents in brain, malondialdehyde (MDA) level, superoxide dismutase (SOD) and GSHPx activities in serum and brain were detected by biochemistry method. Results In serum and brain of senile mice,the contents of NO and MDA increased,the activities of SOD and GSHPx decrease. In addition, the LF in brain also elevated. Resveratrol administration of 15, 30 mg/kg showed different degrees of antagonistic effect on the increase of MDA and NO levels, elevated the SOD and GSHPx activities in serum and brain, decrease LF level in brain. Conclusion Resveratrol may postpone senility by eliminating oxygen free radicals and antilipoperoxidation. ......

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