冠心病；对氧磷酶；基因多态性；相关性_

对氧磷酶1 192位GlnArg基因多态性与冠心病的相关性

http://www.100md.com 《中华首席医学网》 2006年第3期

冠心病；对氧磷酶；基因多态性；相关性,,冠心病；对氧磷酶；基因多态性；相关性,对氧磷酶1192位GlnArg基因多态性与冠心病的相关性,摘要,关键词,1材料与方法,2结果,3讨论,参考文献

     摘要：目的确定对氧磷酶1(PON1)基因192位GlnArg多态性与陕西地区汉族冠心病(CHD)患者发病之间的关系。方法对动脉造影确诊的222例冠心病患者和164例非冠心病患者，采用PCR酶切法检测PON1基因192位GlnArg多态性并进行对比分析。结果陕西地区汉族人群等位基因R和Q频率分别为60.23%和39.77%，其中CHD组RR、QR、QQ基因型分别占41.44%、39.64%、18.92%，对照组RR、QR、QQ基因型分别占35.98%、45.73%、18.29%；CHD组等位基因R频率占61.26%，Q频率占38.74%，对照组的等位基因R频率占58.84%，Q频率占41.56%，组间比较无显著性差异(P>0.05)；心肌梗死和非心肌梗死、冠状动脉病变不同程度间等位基因R和Q频率及RR、QR、QQ基因型之间无显著性差异(P>0.05)。结论陕西汉族人群PON1192位GlnArg基因多态性与CHD发病之间无相关性。

     关键词：冠心病；对氧磷酶；基因多态性；相关性

    Clinical study on the relationship between PON1 192 GlnArg polymorphism and Han patients with Coronary heart disease in Shaanxi

    Su Xianming, Cui Changcong, Cui Hanbin, Wang Xinyang

    (Department of Cardiology, the First Affiliated Hospital, Medical School of Xian Jiaotong University; Department of Cardiology of Shaanxi Peoples Hospital; Institue of Urinary Surgery, the First Affiliated Hospital, Medical School

    of Xian Jiaotong University, Xian 710061, China)

    ABSTRACT: Objective To investigat the relationship between PON1 192 GlnArg gene polymorphisms and coronary artery lesions in Shaanxi Han Chinese. Methods A total of 222 cases with one or more than two branches narrow (≥50%) and 164 cases with no coronary artery narrow(<30%), were diagnosed by coronary angiography. PON1 192 GlnArg gene polymorphisms were tested by PCRrestriction enzyme digestion in these two groups and analyzed. Results The frequencies of Arg (R) and Gln (Q) in Han population of Shaanxi province were 60.23% and 39.77%, respectively. The frequencies of RR, QR and QQ genotypes of PON in CHD group were 41.44%, 39.64% and 18.92%, respectively; and those in control group were 35.98%, 45.73% and 18.29%, respectively; the frequencies of R and Q allele in CHD group were 61.26% and 38.74%, and those in control group were 58.84% and 41.56%. No differences were found in PON gene GlnArg polymorphisms between myocardial infarction and non infarction groups, and no differences were found among different narrow degrees of coronary artery (P>0.05). Conclusion There was no relationship between PON1 192 GlnArg gene polymorphisms and Shaanxi Han patients with coronary heart disease. ......

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