二硝基氯苯引起大鼠结肠炎与神经源性肠炎的关系
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吴星宇, 潘 慧, 黄 鹏, 吴 彬, 蒋惠君,
结肠炎;神经源性炎症;2,4-二硝基氯苯;大鼠,吴星宇,潘慧,黄鹏,吴彬,梅林,蒋惠君,吴星宇,通讯作者,Dinitrochlorobenzene-ind
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吴星宇, 潘慧, 黄鹏, 吴彬, 梅林, 北京大学医学部生理学与病理生理学系 北京市 100083
蒋惠君, 北京大学医学部病理学系 北京市 100083
吴星宇, 1994年武汉华中农业大学学士, 讲师, 主要从事动物生理学和病理生理学研究.
北京市自然科学基金资助项目, No. 7063083
通讯作者: 梅林, 100083, 北京市海淀区学院路38号, 北京大学医学部生理学与病理生理学系. linmei@bjmu.edu.cn
电话: 010-82801477 传真: 010-82801477
收稿日期: 2006-05-08 接受日期: 2006-05-22
Dinitrochlorobenzene-induced colitis and its correlations with neurogenic inflammation of gut in rats
Xing-Yu Wu, Hui Pan, Peng Huang, Bin Wu, Hui-Jun Jiang, Lin Mei
Xing-Yu Wu, Hui Pan, Peng Huang, Bin Wu, Lin Mei, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China
Hui-Jun Jiang, Department of Pathology, Peking University Health Science Center, Beijing 100083, China
Supported by the Natural Science Foundation of Beijing, No. 7063083
Correspondence to: Lin Mei, Department of Physiology and Pathophysiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100083, China. linmei@bjmu.edu.cn
Received: 2006-05-08 Accepted: 2006-05-22
Abstract
AIM: To explore the immune mechanism of ulcerative colitis as well as the relationship between ulcerative colitis and enteric nervous system.
METHODS: Male Sprague Dawley rats were divided into 2, 4-dinitrochlorobenzene (DNCB) groups and ethanol (control) group. After sensitized by DNCB smeared on the abdominal skin, the rats were challenged with DNCB by enema or intrathecal injection. The weight, stool viscosity and hematochezia were observed and accumulated as the disease active index (DAI) score; the colon pathological score was achieved by macropathology and HE staining of section prepared for microscopy; and the activity of leukocyte migration inhibitory factor (LMIF) was determined by immunofluorescence staining in colon tissues.
RESULTS: In the rats treated with 4 and 8 g/L DNCB enema, the macropathological and microscopic scores were significantly higher than those in the controls (macropathological: 2 ......
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