胃癌组织中肿瘤相关基因甲基化及其表达与叶酸和代谢酶MTHFR基因多态性的关系
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翁玉蓉, 房静远, 孙丹凤, 陈朝飞, 陆 嵘,
胃癌;肿瘤相关基因;DNA甲基化;叶酸;MTHFR;基因多态性翁玉蓉,房静远,孙丹凤,陈朝飞,陆嵘,顾伟齐,朱红音.胃癌组织中肿瘤相关基因甲基化及其表达与叶酸和代谢酶MTHFR基因多态性的关系.
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翁玉蓉, 房静远, 孙丹凤, 陈朝飞, 陆嵘, 顾伟齐, 朱红音, 上海交通大学医学院附属仁济医院, 上海市消化疾病研究所 上海市 200001
翁玉蓉, 2006年获上海交通大学医学院附属仁济医院消化内科硕士学位, 主要从事表观遗传修饰与消化系肿瘤关系的研究.国家自然科学基金资助项目, No. 30470781
上海市科委重大项目, No. 04DZ14006
上海市重点学科建设项目, No. Y0205
通讯作者: 房静远, 200001, 上海市山东中路145号, 上海交通大学医学院附属仁济医院, 上海市消化疾病研究所. jingyuanfang@yahoo.com
电话: 021-63200874
收稿日期: 2006-05-15 接受日期: 2006-05-26
Methylation and expression of tumor-related genes and their associations with folate and MTHFR gene polymorphisms in gastric cancerous tissues
Yu-Rong Weng, Jing-Yuan Fang, Dan-Feng Sun,Zhao-Fei Chen, Rong Lu, Wei-Qi Gu, Hong-Yin Zhu
Yu-Rong Weng, Jing-Yuan Fang, Dan-Feng Sun, Zhao-Fei Chen, Rong Lu, Wei-Qi Gu, Hong-Yin Zhu, Shanghai Institute of Digestive Diseases; the Affiliated Renji Hospital of Shanghai Jiaotong University, Shanghai 200001, China
Supported by Natural Science Foundation of China, No. 30470781; the Key Project Foundation of Science Committee, No. 04DZ14006; and the Key Subject Foundation of Shanghai Municipality, No. Y0205
Correspondence to: Dr. Jing-Yuan Fang, Shanghai Institute of Digestive Disease, the Affiliated Hospital of Shanghai Jiaotong University. Shanghai 200001, China. jingyuanfang@yahoo.com
Received: 2006-05-15 Accepted: 2006-05-26
Abstract
AIM: To investigate the methylation and expression of c-myc oncogenes,p16INK4A, p21WAF1, hMLH1 and hMSH2 tumor suppressor genes, and their associations with folate and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in gastric cancerous tissues.
METHODS: Paired samples of primary gastric cancer and corresponding para-cancerous, non-cancerous gastric mucosa were obtained from surgically resected specimens of 38 patients, and the latter were used as controls. Folate concentration was detected by FOL ACS: 180 automated chemiluminescence system ......
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