食管鳞癌癌细胞Survivin蛋白及其体视学参数的测定
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韩 永, 徐燕杰, 余 琦, 杨 敏, 赵 敏,
食管肿瘤;Survivin;免疫组化;体视学,韩永,余琦,杨敏,赵敏,周会芹,徐燕杰,韩永,通讯作者,ExpressionofSurvivinp
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韩永, 余琦, 杨敏, 赵敏, 周会芹, 解放军总医院第二附属医院病理科 北京市 100091
徐燕杰, 解放军总医院第二附属医院医务部 北京市 100091
韩永, 2005年解放军总医院病理学硕士, 主管技师, 从事病理实验工作十余年.
通讯作者: 韩永, 100091, 北京市, 解放军总医院第二附属医院病理科. frankbj72@163.com
电话: 010-66775260
收稿日期: 2006-06-21 接受日期: 2006-07-10
Expression of Survivin protein and measurements of stereology parameters in esophageal squamous carcinoma
Yong Han, Yan-Jie Xu, Qi Yu, Min Yang, Min Zhao, Hui-Qin Zhou
Yong Han, Qi Yu, Min Yang, Min Zhao, Hui-Qin Zhou,Department of Pathology, the Second Affiliated Hospital of Chinese PLA General Hospital, Beijing 100091, China
Yan-Jie Xu,Department of Medical Administration, the Second Affiliated Hospital of Chinese PLA General Hospital, Beijing 100091, China
Correspondence to:Dr. Yong Han, Department of Pathology, the Second Affiliated Hospital of Chinese PLA General Hospital, Beijing 100091, China. frankbj72@163.com
Received:2006-06-21 Accepted:2006-07-10
Abstract
AIM: To investigate the expression of Survivin in esophageal squamous carcinomas (ESC) and measure the stereology parameters of ESC cells.
METHODS: SP immunohistochemistry was used to detect the expression of Survivin protein in 52 ESC patients. Thirty Survivin-positive ESC cells were measured with image analyze system under microscope. The data for the stereological analysis include the body density of nucleus (Vvn), the surface area density of nucleus (Svn), the mean volume of nucleus (V), the surface area of nucleus (S), the mean free path of nucleus (λ), the number density of nucleus (Nv), and the mean curvature density of nucleus (Kv). The differences of the parameters were compared among the tumors with different degrees.
RESULTS: The positive rate of Survivin protein was 57.7% in ESC, and up-regulated expression of Survivin was strongly associated with poor differentiation (χ2 = 6 ......
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