子宫颈癌；树突状细胞；肿瘤坏死因子α；cmyc_

子宫颈上皮细胞癌变中树突状细胞分布、TNFα、cmyc的表达及其临床意义

http://www.100md.com 《新疆医科大学学报》 2006年第7期

子宫颈癌；树突状细胞；肿瘤坏死因子α；cmyc,,子宫颈癌；树突状细胞；肿瘤坏死因子α；cmyc,摘要,关键

     摘要: 目的: 探讨子宫颈上皮正常对照组织、非典型增生组织及子宫颈癌组织中树突状细胞(DC)的形态分布改变及肿瘤坏死因子α(TNFα)、cmyc表达的意义，以及它们与肿瘤临床病理参数间的关系。方法：应用免疫组化SP法检测子宫颈上皮正常对照组织、非典型增生组织各15例及40例子宫颈癌组中DC的形态分布特征及TNFα、cmyc的表达。结果：子宫颈上皮非典型增生组及子宫颈癌组中DC数量显著高于正常对照组(P<0.001)；子宫颈上皮非典型增生组中DC呈树枝状，有较多分支，子宫颈癌组中DC散在分布，位于癌巢中的DC多呈椭圆形或圆形，而位于间质中的DC呈树枝状，有较多分支；TNFα、cmyc的表达在子宫颈癌组、非典型增生组及正常对照组间差异具有统计学意义(P<0.001)。子宫颈癌中DC的表达与患者的年龄、病理分级、临床分期及肿瘤直径有关(P<0.05)；TNFα的表达与患者的临床分期及肿瘤直径有关，而cmyc的表达仅与患者的临床分期有关(P<0.05)。结论：DC、TNFα、cmyc在子宫颈上皮癌变过程及发展中起重要作用，并且与肿瘤临床病理有密切关系。

    关键词：子宫颈癌；树突状细胞；肿瘤坏死因子α；cmyc

    The expression and clinic implication of dendritic cells, TNFα and cmyc in the carcinogenesis of uterine cervical epithelial tissue

    PENG Yuhua, Lalai·Suzuke, CHEN Wenbin, et al

    (Department of Pathology Affiliated Tumour Hospital, Xinjiang Medical University, Urumqi 830054, China)

    Abstract: Objective: To study the expression and implication of dendritic cells (DC)、TNFαand cmyc in uterine cervical tissue. Methods: Fifteen cases of normal uterine cervix, fifteen cases of cervical epithelial dysplasia and forty cases with cervical cancer were identified the expression of DC, TNFα and cmyc by immunehistochemical method (SP). Results: The number of DC in cervical epithelial dysplasia and cervical cancer was higher than that in normal uterine cervix (P<0.001). The expression of TNFα, cmyc in cervical cancer was higher than that in normal uterine cervix and in cervical epithelial dysplasia (P<0.001). In cervical cancer, the expression of DC was positively related to the age, degree of differentiation, clinical stages and tumor diameter, TNFαwas positively related to clinic stages and tumor diameter, and cmyc was positively related to clinical stages. Conclusion: DC, TNFα, cmyc may play important role in the pathogenesis and development of cervical squmous carcinoma, and they were tightly correlated with clinicopathologic factors, especially DC may act as a predictor of prognosis of cervical cancer. ......

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