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人乳头状瘤病毒感染及端粒酶活性与维吾尔族子宫颈癌的关系
http://www.100md.com 《新疆医科大学学报》 2006年第7期
子宫颈癌;HPV16;端粒酶,,子宫颈癌;HPV16;端粒酶;,摘要,关键词,1材料与方法,2结果,3讨论,参考文献
     摘要: 目的:探讨人乳头瘤病毒(HPV16)感染及端粒酶激活与维吾尔族子宫颈癌的关系。方法:对32例维吾尔族宫颈癌、25例宫颈上皮内瘤变(CIN)及33例慢性宫颈炎患者应用PCR(聚合酶链反应)技术及PCRTRAP(重复序列扩增)法进行HPV16及端粒酶活性检测。结果:(1)端粒酶阳性表达率依次为:CIN>宫颈癌>慢性宫颈炎;CINⅢ级>CINⅠ、Ⅱ级(P<0.05)。端粒酶活性水平:CIN>宫颈癌>慢性宫颈炎(P<0.05);CINⅢ级>CINⅠ、Ⅱ级(P<0.05)。(2)HPV16阳性表达率依次为:宫颈癌>CIN>慢性宫颈炎(P<0.05)。(3)宫颈组织中HPV16及端粒酶协同阳性表达率为:宫颈癌>CIN>慢性宫颈炎(P<0.05);(4)HPV16及端粒酶在宫颈癌早期与晚期、高分化与中低分化组织中表达差异均无统计学意义,在宫颈鳞癌与腺癌中的表达差异无统计学意义(P>0.05)。结论:HPV16感染和端粒酶激活与维吾尔族子宫颈癌的发生密切相关,端粒酶激活是宫颈癌发生的早期事件。

    关键词:子宫颈癌;HPV16;端粒酶;

    A study on the correlation between humanpapillomavirus infection and telomerase activity in cervical cancer in Uygur women

    Zufeiya·Aili, Lalai·Suzuke

    (Department of Gynecological Oncology, First Affiliated Hospital, Xinjiang Medical University,Urumqi 830054, China)

    Abstract: Objective: To study the correlation between human papillomavirus and telomerase activity in cervical cancer in Uygur women. Methods: HPV16 was determined by PCR and telomerase activity was detected by TRAPPCR in 32 cervical cancer, 25 cervical intraepithelial neoplasia (CIN) and 33 chronic cervicitis cases. Results: (1) With regard to the positive expression rate of telomerase CIN>cervical cancer>chronic cervicitis (P<0.05); CINⅢ>CINⅠ, Ⅱ, (P<0.05). (2) The positive rate of HPV16 was: cervical cancer> CIN>chronic cervicitis (P<0.05). (3) On expression strength of telomerase and HPV16: cervical cancer>CIN>chronic cervicitis (P<0.05). (4) Positive rate of HPV16 and telomerase in cervical cancer did not correlate with clinical staging, histological grading, and histologic subtypes (P>0.05). Conclusion: The HPV16 infection is closely related to cervical carcinoma in Uygur women by activation of telomerase and reactivation of telomerase is an early event and may play an important role in Uygur women during cervical carcinogenesis and progression. ......

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