辛伐他汀；急性冠脉综合征；脂代谢紊乱；达标_

维吾尔族急性冠脉综合征患者早期短程应用辛伐他汀的临床效果

http://www.100md.com 《新疆医科大学学报》 2006年第7期

辛伐他汀；急性冠脉综合征；脂代谢紊乱；达标,,辛伐他汀；急性冠脉综合征；脂代谢紊乱；达标,摘要,关键词,1材料与方法,2结果,3讨论,参

     摘要: 目的：探讨不同剂量辛伐他汀早期治疗急性冠脉综合征(ACS)脂代谢紊乱的调脂疗效及达标率。方法：按照我国冠心病血脂异常防治目标值选择血脂未达标的100例维吾尔族患者，随机分为2组：A组(50例)每晚服用辛伐他汀40 mg，B组(50例)每晚服用辛伐他汀20 mg，服药前及服药1周后测定总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酸激酶(CK)水平，并进行对照分析。结果：A组服药1周后TC、LDLC下降率、达标率优于B组(P<0.05)，同时能明显的降低甘油三酯；2组不良反应均轻微，无明显差异。结论：维吾尔族ACS脂代谢紊乱患者早期应用辛伐他汀治疗能短时间内有效调脂，提高达标率，且有效、较安全、耐受性好。

    关键词：辛伐他汀；急性冠脉综合征；脂代谢紊乱；达标

    Clinical study of different dosage simvastatin on the Uygur acute coronary syndrome patients in achieving target blood lipid level after short time medication

    Guljahra·Ubul, Mamat·Abdureyim

    (Second Department of Geriatrics, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China)

    Abstract: Objective: This study is designed to evaluate the efficacy and safety of different dosage simvastatin on the acute coronary syndrome (ACS) patients with lipid disorders after short time medication. Method: According to the International Heart Association and WHO criteria of diagnosis, choose some Uygur patients who diagnosed as ACS were chosen and measure their blood lipid level and liver function (TC, TG, LDLC, HDLC, ALT, AST, CK). According to the China Heart Association Suggestions, 100 ACS Uygur patients with lipid disorders were divided into two groups randomly. In group A (n=50), simvastatin 40 mg/d was given at night; and in group B (n=50) simvastatin 20 mg/d was given at night. blood lipid level and liver function were measured after one week treatment. Results: There were significant reductions of TC, LDLC and higher target bloodlipid goal rate in group A compared with group B. Group A was effective in reducing TG. In both groups adverse reaction was mild, similar. Conclusion: ACS patients with lipid disorders in Uygur population, the early usage of simvastatin 40 mg/d seems very effective in hightenirg target blood lipid goal rate after short time medication. Simvastatin 40 mg/d will be good in safety, efficacy and tolerance. ......

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