胃癌组织中幽门螺杆菌cagA和vacA的表达及与其感染的相关性
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佟书娟, 陈 军, 詹 瑧, 杨丹丹, 刘亚平
胃癌;幽门螺杆菌;细胞毒素相关基因A;空泡细胞毒素基因A佟书娟,陈军,詹瑧,杨丹丹,刘亚平.胃癌组织中幽门螺杆菌cagA和vacA的表达及与其感染的相关性. 世界华人消化杂志2006;14
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佟书娟, 詹瑧, 杨丹丹, 南京中医药大学基础医学院 江苏省南京市 210029
陈军, 中国人民解放军宁夏军区政治部 宁夏回族自治区银川市 750021
刘亚平, 中国人民解放军第5医院病理科 宁夏回族自治区银川市 750004宁夏教育厅科研基金资助项目, No. JY2002125
通讯作者: 佟书娟, 210029, 江苏省南京市, 南京中医药大学基础医学院. tongshujuan6@sina.com
电话: 025-85811925
收稿日期: 2006-05-23 接受日期: 2006-08-10
Expression of Helicobacter pylori cagA and vacA and their correlations with Helicobacter pylori infection in gastric cancer
Shu-Juan Tong, Jun Chen, Zhen Zhan, Dan-Dan Yang, Ya-Ping Liu
Shu-Juan Tong, Zhen Zhan, Dan-Dan Yang, Basic Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Jun Chen, Department of Politics, Ningxia Military Command of Chinese PLA, Yinchuan 750021, Ningxia Hui Autonomous Region, China
Ya-Ping Liu, Department of Pathology, the Fifth Hospital of Chinese PLA, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Supported by the Science Research Foundation from Department of Education of Ningxia Hui Autonomous Region, No. JY2002125
Correspondence to: Shu-Juan Tong, Basic Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province,China. tongshujuan6@sina.com
Received: 2006-05-23 Accepted: 2006-08-10
Abstract
AIM: To explore the expression of H pylori cagA and vacA in gastric cancer and their correlations with H pylori infection.
METHODS: H pylori infection was determined by Warthin-Starry silver staining in gastric cancer (n = 39), gastric mucosal atypical hyperplasia (n = 24) and chronic gastritis (n = 33). Polymerase chain reaction (PCR) was used to detect the expression of H pylori cagA and vacA.
RESULTS: The infection rates of H pylori, cagA+H pylori and vacA+ H pylori in gastric cancer tissues were significantly higher than those chronic gastritis tissue (c2 = 7 ......
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