热水致大鼠慢性萎缩性胃炎胃黏膜组织细胞HSP-70及Fas蛋白表达
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王 磊, 柳 涛, 郑培永, 邢练军, 季 光
清肝活血方;酒精性肝纤维化;肝星状细胞;凋亡王磊,柳涛,郑培永,刑练军,季光.清肝活血方对酒精性肝纤维化大鼠肝星形细胞及肝细胞凋亡的影响. 世界华人消化杂志2006;14(26)2590-
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参见附件。
王磊, 柳涛, 邢练军, 季光, 上海中医药大学附属龙华医院脂肪肝研究室 上海市 200032
郑培永, 上海中医药大学附属龙华医院临床评价中心 上海市 200032
王磊, 上海中医药大学硕士, 主要从事中医药防治肝脏疾病的研究.
上海市科委启明星跟踪计划项目, No. 03QMH1410
通讯作者: 季光, 200032, 上海市宛平南路725号, 上海中医药大学附属龙华医院脂肪肝研究室. jiliver@vip.sina.com
收稿日期: 2006-06-21 接受日期: 2006-07-31
Effect of Qinggan Huoxue recipe on apoptosis of hepatic stellate cells and hepatocytes in rats with alcoholic liver fibrosis
Lei Wang, Tao Liu, Pei-Yong Zheng, Lian-Jun Xing, Guang Ji
Lei Wang, Tao Liu, Lian-Jun Xing, Guang Ji, Laboratory of Liver Steatosis, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Pei-Yong Zheng, Clinic Evaluation Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Supported by the Rising-Star Program of Shanghai Science Commitee, No. 03QMH1410
Correspondence to: Dr. Guang Ji, Laboratory of Liver Steatosis, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. jiliver@vip.sina.com
Received: 2006-06-21 Accepted: 2006-07-31
AbstractAIM:To evaluate the influences of Qinggan Huoxue recipe (QHR) on the apoptosis of hepatic stellate cells (HSC) and hepatocytes in alcoholic liver fibrosis rats.
METHODS: Rat model of alcoholic liver fibrosis were established mainly through alcohocol, and then the rats were divided into 6 groups: QHR groups [low dose: 4.75 g/(kg•d), moderate dose: 14.25 g/(kg•d), high dose: 28.5 g/(kg•d)] and control groups (normal, model, and Essentiale control). Colorimetry was used to detect the serum levels of alanine aminotransferase (ALT), aspartate transaminase (AST) and gamma-glutamyltranspeptidase (g-GT). The degrees of inflammation and fibrosis were evaluated by HE and Masson stainings. TUNEL and TUNEL-a-SMA methods were used to detect the apoptosis of HSC and hepatocytes, respectively ......
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