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饮酒对慢性乙型病毒性肝炎患者肝脏炎症和纤维化的病理影响
http://www.100md.com 牛凤丽, 洪尚游, 万谟彬
饮酒;酒精性肝病;乙型肝炎病毒;乙型病毒性肝炎;肝脏病理牛凤丽,洪尚游,万谟彬.饮酒对慢性乙型病毒性肝炎患者肝脏炎症和纤维化的病理影响. 世界华人消化杂志2006;14(26)2610-2
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     牛凤丽, 同济大学附属东方医院急诊创伤医学部 上海市200120

    洪尚游,
万谟彬, 长海医院慢性肝病病房 上海市 200433

    牛凤丽,
2002年上海第二医科大学硕士研究生, 主治医师, 主要从事消化系疾病研究.

    通讯作者:
牛凤丽, 200120, 上海市即墨路150号, 同济大学附属东方医院急诊创伤医学部. niufengli@yahoo.com.cn

    电话:
021-38804518-6176

    收稿日期:
2006-07-11 接受日期: 2006-07-31

    
Impact of alcohol intake on liver inflammation and fibrosis in patients with chronic hepatitis B

    Feng-Li Niu, Shang-You Hong, Mo-Bin Wan

    Feng-Li Niu, Emergency Trauma Medical Board, Oriental Hospital Affiliated to the University of Tongji, Shanghai 200120, China

    Shang-You Hong,
Mo-Bin Wan, Hepatopathy Ward, Changhai Hospital, Shanghai 200433, China

    Correspondence to:
Feng-Li Niu, Emergency Trauma Medical Board, Oriental Hospital Affiliated to the University of Tongji, Shanghai 200120, China. niufengli@yahoo.com.cn

    Received:
2006-07-11 Accepted: 2006-07-31

    AbstractAIM:To pathologically investigate the roles of alcohol in hepatic injuries in patients with chronic hepatitis B.

    METHODS:A total of 84 patients were divided into 3 groups (alcohol intake, simple chronic hepatitis B, and chronic hepatitis B plus alcohol intake, named group A, B and C, respectively), which enrolled 21, 30 and 33 cases, respectively. Pathological changes including inflammatory activity, fibrosis and fatty degeneration in sections of liver biopsy from the patients were analyzed retrospectively by semi-quantitative evaluation.

    RESULTS:The inflammatory activity (8.73 ± 6.93 vs 5.20 ± 3.41, P < 0.05) and fibrosis index (7.67 ± 5.34 vs 5.40 ± 3.94, P < 0.05) were significantly increased in group C than those in group B ......

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