肿瘤新生血管生成抑制剂-肿瘤抑素的研究进展
肿瘤抑素；肿瘤新生血管生成抑制剂；内皮细胞；αvβ3整合素,,肿瘤抑素；肿瘤新生血管生成抑制剂；内皮细胞；αvβ3整合素,1肿瘤抑素的来源、结构和分
【摘要】 肿瘤的生长和转移都离不开新生血管的生成，肿瘤抑素是一种来源于基膜胶原IV(Col IV)的蛋白片断，具有抗肿瘤新生血管生成和抑制肿瘤细胞增殖的双重活性，能特异性地抑制肿瘤血管内皮细胞蛋白的合成。对其进一步的研究证实肿瘤抑素是一种内源性的病理血管生成的抑制剂，具有潜在的药用价值。本文主要概述肿瘤抑素的来源、结构和分布,活性研究,作用机制及其与基质金属蛋白酶(MMP)的关系等最新研究进展和应用前景。【关键词】 肿瘤抑素；肿瘤新生血管生成抑制剂；内皮细胞；αvβ3整合素
Advances of an inhibitor of tumor angiogenesis-Tumstatin
YAN Ting-dong，ZHAO Qi-ren.
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192,China
【Abstract】 Tumors cannot grow or metastasize without the recruitment of new blood vessels. Tumstatin is a C-terminal NC1 fragment of type IV collagen α3 chain that inhibits pathological angiogenesis and suppresses proliferation of endothelial cells and growth of tumors. Further studies suggest that tumstatin is an endogenous inhibitor of pathological angiogenesis. This review introduced the origin，structure and distribution of tumstatin; the biological activity of tumstatin; the mechanism of tumstatin and the relationship between tumstatin and matrix metalloproteinases; the futures of tumstatin. ......
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