QIN Xin1,2, LIU Youª²Ning1, CHEN Liangª²An1, CHEN Tianª²Shi1

    1Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing 100853, China, 2Department of Respiratory Diseases, Second Clinical Hospital, Shanxi Medical University, Taiyuan 030072, China

    ¡¾Abstract¡¿ AIM: To investigate the effects of inverse ratio ventilation(IRV) and positive endª²expiratory pressure(PEEP) on TNFª²¦Á, ILª²8 and ETª²1 in oleic acidª²induced lung injury. METHODS: Sixteen New Zealand rabbits were randomly divided into 2 groups, IRV group(n=8) and PEEP group (n=8). The IRV group were ventilated with a tidal volume(VT) of 12 mL/kg, respiratory rate of 30 breaths/min, I¡ÃE=3¡Ã1 and PEEP of 0 cmH2O; in PEEP group, VT was 10 mL/kg and respiratory rate 40 breaths/min, I¡ÃE=1¡Ã2 and PEEP=20 cmH2O; FiO2=0.5 in both groups. Mixed venous blood 3 mL was taken via right ercernal jugular vein respectively at 0, 30, 60, 90 and 120 min during ventilating. The animals were sacrificed by draining artery blood at the end of experiment. Right lung was cut off for wet/dry weighing and left was lavaged. Concentrations of TNFª²¦Á, ILª²8 and ETª²1 in blood plasma and bronchoalveolar lavage fluid(BALF) were measured by radioimmune assay. RESULTS: Levels of TNFª²¦Á ......