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缺血后处理对兔脊髓缺血再灌注损伤中MDA和SOD的影响
http://www.100md.com 《第四军医大学学报》 2006年第14期
缺血后处理;脊髓缺血;再灌注损伤;丙二醛;超氧化物歧化酶,,缺血后处理;脊髓缺血;再灌注损伤;丙二醛;超氧化物歧化酶,【摘要】,【关键词
     GAO Peng1, XIONG LiZe1, LU ZhiHong1, LI WanPeng2, MENG JingRu3

    1Department of Anesthesiology, Xijing Hospital, 3Department of Pharmacology, School of Basic Medicine, Fourth Military Medical University, Xian 710033, China, 2 Department of Anesthesiology, Peoples Hospital of Weinan City, Weinan 714000, China

    【Abstract】 AIM: To investigate the impact of postischemic treatment on malondialdehyde (MDA) and superoxide dismutase (SOD) during spinal cord ischemia/reperfusion injury in rabbits. METHODS: Twentyfour male New Zealand rabbits were randomly divided into 4 groups (n=6 each):control group, postischemic treatment for 15, 30 and 60 s groups (PA, PB and PC groups).Rabbits in the control group underwent the occlusion of abdominal aorta for 15 min followed by reperfusion for 1 h. In PA,PB and PC groups, rabbits underwent the 3 cycles of ischemia/reperfusion with the duration of 15 s/15 s, 30 s/30 s and 60 s/60 s respectively just after 15 min occlusion of the abdominal aorta. The MDA and SOD were measured at the 3 different time points:preischemia,10 min after ischemia and 1 h after reperfusion. RESULTS: At 1 h after reperfusion,the MDA concentrations in plasma and spinal cord homogenate in PA and PB groups were significantly lower than those in the control group (P<0.01), but in PC group they were significantly higher than those in the control group (P<0.01). The SOD activities in plasma and spinal cord homogenate in PA and PB groups were significantly higher than those in the control group (P<0.01), while in PC group they were both significantly lower than those in the control group (P<0.01). CONCLUSION: Early and shortterm (15 s/15 s and 30 s/30 s) ischemic postconditioning has an antioxidant potential, and depresses the production of oxygen free radicals and protects the spinal cord from ischemia/reperfusion injury. ......

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