Origins, Lineage-Specific Expansions, and Multiple Losses of Tyrosine Kinases in Eukaryotes
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分子生物学进展 2004年第12期
Figures 2 and 3 of this article should have appeared as shown below. The publisher regrets the error.
FIG. 2.— Kinase phylogeny and conservation of domain organization. The kinase domains of tyrosine kinases were aligned and used for phylogenetic reconstruction. The phylogeny is shown on the left. The branches were labeled according to the taxa of the source sequences. Subfamilies were classified based on the scheme outlined in Materials and Methods, except the MUSK subfamily. For subfamilies with domains or motifs identified in addition to kinases, their organizations were shown in the middle. In subfamilies with more than one domain configuration, they are enclosed in gray background. The conservation of domain organization is shown on the right. The species name abbreviations are shown on the top. The circle indicates that the organism has at least one tyrosine kinase that belongs to this subfamily. The circles were color-coded based on the resemblance of subfamily members in an organism to the domain organization shown in the middle: black, same domain composition and arrangement; blue, similar but with fewer or more non-kinase domains; red, no identical domain outside of the kinase domain; white, not determined.
FIG. 3.— Differential expansion of tyrosine kinase subfamilies. Subfamilies of tyrosine kinases were delineated based on the phylogeny of the kinase domain sequences and their domain organizations. A, Phylogeny of tyrosine kinase subfamily representatives indicating a monophyly of the tyrosine kinase family and subfamily relationships. Bootstrap values are shown next to the nodes. Outgroups are boldfaced and italicized. Arrowheads indicate subfamilies defined based on their sister group relationships to subfamilies with C. elegans tyrosine kinases. Arrows indicate clades that do not have C. elegans genes and do not have sufficient support for their affiliation with subfamilies with C. elegans sequences. B, The number of subfamily members in different metazoan genomes. Species abbreviations are as defined in figure 1. Subfamilies with more than 15 members were truncated with the gene number indicated. The full names for gene acronyms can be found in Supplement A of the Supplementary Material online.(Shin-Han Shiu and Wen-Hsi)
FIG. 2.— Kinase phylogeny and conservation of domain organization. The kinase domains of tyrosine kinases were aligned and used for phylogenetic reconstruction. The phylogeny is shown on the left. The branches were labeled according to the taxa of the source sequences. Subfamilies were classified based on the scheme outlined in Materials and Methods, except the MUSK subfamily. For subfamilies with domains or motifs identified in addition to kinases, their organizations were shown in the middle. In subfamilies with more than one domain configuration, they are enclosed in gray background. The conservation of domain organization is shown on the right. The species name abbreviations are shown on the top. The circle indicates that the organism has at least one tyrosine kinase that belongs to this subfamily. The circles were color-coded based on the resemblance of subfamily members in an organism to the domain organization shown in the middle: black, same domain composition and arrangement; blue, similar but with fewer or more non-kinase domains; red, no identical domain outside of the kinase domain; white, not determined.
FIG. 3.— Differential expansion of tyrosine kinase subfamilies. Subfamilies of tyrosine kinases were delineated based on the phylogeny of the kinase domain sequences and their domain organizations. A, Phylogeny of tyrosine kinase subfamily representatives indicating a monophyly of the tyrosine kinase family and subfamily relationships. Bootstrap values are shown next to the nodes. Outgroups are boldfaced and italicized. Arrowheads indicate subfamilies defined based on their sister group relationships to subfamilies with C. elegans tyrosine kinases. Arrows indicate clades that do not have C. elegans genes and do not have sufficient support for their affiliation with subfamilies with C. elegans sequences. B, The number of subfamily members in different metazoan genomes. Species abbreviations are as defined in figure 1. Subfamilies with more than 15 members were truncated with the gene number indicated. The full names for gene acronyms can be found in Supplement A of the Supplementary Material online.(Shin-Han Shiu and Wen-Hsi)