双歧杆菌对内毒素损伤幼年大鼠抗氧化作用的影响
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王 玮, 李金梅, 马文旭, 孙 梅
双歧杆菌;内毒素;抗氧化作用;超氧化物歧化酶;幼年大鼠,王玮,孙梅,李金梅,马文旭,通讯作者:,Effectofbifidobacteria
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王玮, 孙梅, 中国医科大学附属第二临床学院儿科 辽宁省沈阳市 110004
李金梅, 鸡西矿业集团总医院儿科 黑龙江省鸡西市 158100
马文旭, 大庆油田总医院儿科 黑龙江省大庆市 163001
通讯作者: 孙梅, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属第二临床学院儿科. sunm@cmu2h.com电话: 024-83956503, 83955572
收稿日期: 2006-07-11 接受日期: 2006-08-18
Effect of bifidobacteria on the antioxidation in infant rats with endotoxin-induced injury
Wei Wang, Jin-Mei Li, Wen-Xu Ma, Mei Sun
Wei Wang, Mei Sun,Department of Pediatrics, the Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Jin-Mei Li,Department of Pediatrics, General Hospital of Jixi Mining Bureau, Jixi 158100, Heilongjiang Province, China
Wen-Xu Ma,Department of Pediatrics, Daqing Oilfield General Hospital, Daqing 163001, Heilongjiang Province, China
Correspondence to:Mei Sun, Department of Pediatrics, the Second Affiliated Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. sunm@cmu2h.com
Received: 2006-07-11 Accepted:2006-08-18
Abstract
AIM: To investigate the changes of superoxide dismutase (SOD) during the endotoxin-induced injuries in infant rats and the protective effect of bifidobacteria.
METHODS: A total of 160 rats were randomly and averagely divided into group C, E, Tc and and T. The rats in group E were intraperitoneally injected with lipopolysaccharide (LPS), and those in group T were intragastrically administrated with bifidobacteria suspension 7 d in advance. Meanwhile, the rats in group C were intraperitoneally injected with normal saline and those in group Tc were intragastrically administrated with normal saline 7 d before intraperitoneal injection of LPS. The tissue injuries of the ileum were observed under naked eyes and light microscope, and the serum and tissue SOD activity were detected at different time points.
RESULTS: The rats in group T had milder symptoms such as cachexia, anorexia, abdominal distention, diarrhea, intestinal congestion and edem, and distension of the intestine than those in group E ......
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