十二指肠间质瘤临床分析30例
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张 勇, 陈 凛
十二指肠间质瘤;核分裂象;预后;根治术,张勇,陈凛,通讯作者:,Clinicalanalysisof30patientswithduodenalgastrointes
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张勇, 陈凛, 中国人民解放军总医院普通外科 北京市 100853
通讯作者: 陈凛, 100853, 北京市, 中国人民解放军总医院普通外科. chenlinbj@vip.sina.com
电话: 010-66937846
收稿日期: 2006-07-25 接受日期: 2006-09-01
Clinical analysis of 30 patients with duodenal gastrointestinal stromal tumors
Yong Zhang, Lin Chen
Yong Zhang, Lin Chen,Department of General Surgery, General Hospital of Chinese PLA, Beijing 100853, China
Correspondence to: Lin Chen, Department of General Surgery, General Hospital of Chinese PLA, Beijing 100853, China. chenlinbj@vip.sina.com
Received:2006-07-25 Accepted:2006-09-01
Abstract
AIM: To investigate clinical characteristics, surgical treatment and prognosis factors for the patients with duodenal gastrointestinal stromal tumors (GISTs).
METHODS: The clinical data of 30 patients with duodenal GISTs from 1993 to 2006 were retrospectively analyzed. The survival rates were calculated by Kaplan-Meier method, and the prognosis factors were analyzed by univariate analysis, and Cox model multivariate analysis.
RESULTS: Common symptoms of duodenal GISTs were abdominal pain and alimentary tract hemorrhage. Common lesions of duodenal GISTs were located in the descending portion. The overall 1-, 3-, and 5-year survival rate were 92.95%, 84.87%, and 69.15%, respectively. Univariate analysis showed that Fletcher’s classification (χ2 = 10.570,P = 0.0143), tumor size (χ2 = 7.883, P = 0.0485), mitosis (>5, ≤5: χ2 = 14.155, P = 0.0002), distant metastases (χ2 = 22.519, P = 0.0000) were significant prognostic factors. The number of patients with radical partial resection was markedly larger than that without radical partial resection (χ2 = 17.8180, P = 0.0000). COX multivariate analysis indicated that only mitosis was an independent prognostic factor.
CONCLUSION: Surgical treatment of duodenal GISTs should be based on radical partial resection, and mitosis may be an independent prognostic factor for patients with duodenal GISTs ......
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