结直肠癌手术前后血清P53抗体, CEA及CA19-9的检测意义
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张 宏, 丛进春, 陈春生, 乔 雷, 冯 勇,
结直肠癌;血清P53抗体;癌胚抗原;糖类抗原CA19-9,结直肠癌手术前后血清P53抗体,CEA及CA19-9的检测意义,张宏,丛进春,陈春生,乔雷,冯勇,刘恩卿,通讯作者:,Pre-andpos
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张宏, 丛进春, 陈春生, 乔雷, 冯勇, 刘恩卿, 中国医科大学附属第二医院(盛京医院)普外科 辽宁省沈阳市 110004
通讯作者: 张宏, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属第二医院(盛京医院)普外科.
zhanghong1203@yahoo.com.cn
电话: 024-83955074 传真: 024-23862410
收稿日期: 2006-07-10 接受日期: 2006-07-31
Pre- and post-operative sequential changes of serum P53 antibody, carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with colorectal cancer
Hong Zhang, Jin-Chun Cong, Chun-Sheng Chen, Lei Qiao, Yong Feng, En-Qing Liu
Hong Zhang, Jin-Chun Cong, Chun-Sheng Chen, Lei Qiao, Yong Feng, En-Qing Liu.Department of General Surgery, the Second Affiliated Hospital (Shengjing Hospital) of China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to: Hong Zhang,Department of General Surgery, the Second Affiliated Hospital (Shengjing Hospital) of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province,China. zhanghong1203@yahoo.com.cn
Received:2006-07-10 Accepted:2006-07-31
Abstract
AIM: To investigate the value of sequential change of pre- and post-operative serum P53 antibodies, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients with colorectal cancer.
METHODS: A total of 132 patients with colorectal cancer and 36 ones with benign lesions (as controls) were included in this prospective study. The blood samples were collected 1 h before operation and 30 d postoperatively. The presence of serum P53 antibody was determined by enzyme-linked immunosorbent assay (ELISA). The levels of serum CEA and CA19-9 were detected using radioimmunoassay (RIA).
RESULTS: The positive rate of serum P53 antibodies in patients with colorectal cancer were significantly higher than that in ones with benign disease (χ2 = 18.11, P < 0.0001). Thirty-nine (74%) of P53 seropositive patients showed negative conversion 1 mo after operation, including 3 cases (33%) in palliative surgery group and 36 cases (82%) in radical operation group (χ2 = 9 ......
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