非酒精性脂肪肝大鼠瘦素水平及丹参注射液的预防作用
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黄妙珍, 孙丽伟, 付珍春, 朱善济, 王祖武,
脂肪肝;瘦素;丹参注射液;大鼠,黄妙珍,孙丽伟,付珍春,朱善济,王祖武,任晓华,陈兆军,通讯作者:,Levelofleptininnona
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黄妙珍, 孙丽伟, 付珍春, 杭州师范学院附属医院消化科 浙江省杭州市 310015
朱善济, 王祖武, 杭州师范学院形态实验室 浙江省杭州市 310036
任晓华, 陈兆军, 杭州师范学院附属医院放射免疫中心 浙江省杭州市 310015
通讯作者: 黄妙珍, 310015, 浙江省杭州市温州路126号, 杭州师范学院附属医院消化科. hmzhope@sina.com
电话: 0571-88303653
收稿日期: 2006-07-25 接受日期: 2006-08-22
Level of leptin in nonalcohic fatty liver of rats and preventive effects of Salvia miltiorrhiza injection
Miao-Zhen Huang, Li-Wei Sun, Zhen-Chun Fu, Shan-Ji Zhu, Zu-Wu Wang, Xiao-Hua Ren, Zhao-Jun Chen
Miao-Zhen Huang, Li-Wei Sun, Zhen-Chun Fu,Department of Digestive Diseases, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China
Shan-Ji Zhu, Zu-Wu Wang,Department of Morphous Lab, Hangzhou Normal University, Hangzhou 310036, Zhejiang Province, China
Xiao-Hua Ren, Zhao-Jun Chen,Department of Radioimmune Center, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China
Correspondence to:Miao-Zhen Huang, Department of Digestive, the Affiliated Hospital of Hangzhou Normal University, 126 Wenzhou Road, Hangzhou 310015, Zhejiang Province, China. hmzhope@sina.com
Received:2006-07-25 Accepted:2006-08-22
Abstract
AIM: To detect the level of leptin in the nonalcohic fatty liver of rats and the preventive effects of Salvia miltiorrhiza (SM) injection.
METHODS: Male Sprague Dawley rats were selected randomly and given a fat-rich diet for 8 wk. The rats with fatty livers were randomly divided into model group, high-dose SM group, low-dose SM group and reduced glutathione control group. The serum level of leptin was detected by radioimmunoassay (RIA). The pathological changes in rat livers were observed.
RESULTS: The index of rat nonalcohic fatty liver was significantly higher than that in normal rats (3.09% ± 0.24% vs 2.63% ± 0.19%, t = 4.61, P = 0.00), while the level of leptin was markedly lower than that in normal rats (1 ......
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