Granzyme B在原发及淋巴转移性胃癌细胞中的差异表达及其与肿瘤血管生成的关系
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周业江, 熊玉霞, 易国平, 徐 亮, 夏 冬,
胃癌;颗粒酶B;血管生成;淋巴转移周业江,熊玉霞,易国平,徐亮,夏冬,魏仁智.GranzymeB在原发及淋巴转移性胃癌细胞中的差异表达及其与肿瘤血管生成的关系. 世界华人消化杂志2006;
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周业江, 易国平, 夏冬, 魏仁智, 徐亮, 泸州医学院附属医院普外科 四川省泸州市 646000
熊玉霞, 泸州医学院药理教研室 四川省泸州市 646000
周业江, 泸州医学院附属医院普外科副教授, 医学博士, 硕士研究生导师, 主要从事胃肠肿瘤的基础与临床研究.
国家自然科学基金资助项目, No. 30672058
通讯作者: 周业江, 646000, 四川省泸州市江阳区太平街25号, 泸州医学院第一附属医院普外科. zyj7525@163.com
电话: 0830-3165421 传真：0830-3165421
收稿日期: 2006-08-16 接受日期: 2006-09-16
Differential expression of Granzyme B in tumor cells between primary and metastatic gastric cancer and its potential role in tumor angiogenesis
Ye-Jiang Zhou, Yu-Xia Xiong, Guo-Ping Yi, Liang Xu, Dong Xia, Ren-Zhi Wei
Ye-Jiang Zhou, Guo-Ping Yi, Liang Xu, Dong Xia, Ren-Zhi Wei, Department of General Surgery, the Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
Yu-Xia Xiong, Department of Pharmacology, Luzhou Medical College, Luzhou 646000, Sichuan Province, China
Supported by National Natural Science Foundation of China, No. 30672058
Correspondence to: Dr. Ye-Jiang Zhou, Department of General Surgery, the Affiliated Hospital of Luzhou Medical College, 25 Taiping Street, Jiangyang District, Luzhou 646000, China. zyj7525@163.com
Received: 2006-08-16 Accepted: 2006-09-16
Abstract
AIM:To investigate the potential role of Granzyme B (GrB) in the biological behavior of gastric cancer, such as angiogenesis and lymphatic metastasis.
METHODS: The identification of GrB expression in gastric cancer cells was performed immunohistologically in patients with primary gastric cancers (PGC, n = 35) and lymphoid metastatic gastric cancer (LMGC, n = 23), and GrB+ cytotoxic T lymphocytes (CTL) served as positive internal control.The antibodies recognizing vascular endothelial growth factor (VEGF) and CD34 were employed to detect the VEGF expression and microvascular density (MVD), respectively.
RESULTS: The positive rate of GrB expression was relatively lower in PGC with lymphoid metastasis than that without metastasis, but no significant difference was observed (P = 0 ......
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