[摘要] 目的 探讨血清C3、C4对监测系统性红斑狼疮(SLE)活动性的意义。方法 用速率散射比浊法对92例在我院SLE确诊患者在其SLE缓解期、活动期分别进行补体C3、C4测定，对测定结果进行比较分析。结果 显示血清C3、C4在SLE活动期呈显著性下降(P<0.05)，下降幅度分别为46%、25.6%，C3水平降低更为显著；C3、C4下降结果超过5%者分别为78例、32例，选定人群中C3下降更为广泛。构建C3、C4监测SLE活动性的ROC曲线，C3下面积为0.784，C4为0.541。结论 血清C3可作为用于监测SLE活动性的指标之一，血清C4监测意义劣于C3。

    [关键词] 补体系统；C3；C4；系统性红斑狼疮

    Association study of serum complement C3，C4 level and the disease activity of SLE

    XIE Zhi-xian，LIU Qian.Beijing Hospital,Beijing 100730,China

    [Abstract] Objective To investigate the significance of serum complement C3，C4 changes in monitoring the disease activity of systemic lupus erythematosus(SLE).Methods Ninety-two in-patients with systemic lupus erythematosus(SLE) were evaluated with SLE activity index.The serum levels of C3，C4 were examined respectively in active phase and remission phase.Then analysis was conducted.Results In active phase ......