宫颈癌；多药耐药；免疫组织化学；预后_

早期宫颈癌耐药基因与临床预后关系回顾性研究

http://www.100md.com 《河北北方学院学报》 2006年第1期

宫颈癌；多药耐药；免疫组织化学；预后,,宫颈癌；多药耐药；免疫组织化学；预后,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的:探讨耐药基因p糖蛋白(pgp)、谷胱甘肽s转移酶(GSTπ)、拓扑异构酶Ⅱ(TOpoⅡ)、胸苷酸合成酶(TS)在宫颈癌中的表达及临床意义。方法:应用免疫组织化学方法检测65例宫颈癌中pgp、TOpoⅡ、GSTπ、TS的表达，并分析其与临床预后之间的关系。结果:pgp的表达与肿瘤分化程度、淋巴结转移有关(P<005)，与UICC分期、局部复发无关(P>005)；TOpoⅡ的表达与淋巴结转移、局部复发有关(P<005)，与肿瘤分化程度、UICC分期无关(P>005)；GSTπ的表达与各个指标之间均存在相关(P<005)；TS与淋巴结转移、UICC分期有关(P<005)，与局部复发、肿瘤分化无关(P>005)。经多因素cox比例风险模型分析显示：局部复发、淋巴结转移及TOPOⅡ、GSTπ的表达与宫颈癌患者术后生存率有关(P<005)。结论:宫颈癌中pgp、TOpoⅡ、GSTπ、TS的联合检测对判断宫颈癌的预后十分必要；局部复发、淋巴结转移及TOpoⅡ、GSTπ的表达可作为宫颈癌患者独立的预后因素。

    【关键词】宫颈癌；多药耐药；免疫组织化学；预后

    Retrospective Study on DrugResistance Gene Associated Proteins Expression and Clinical Significance in Early Cervical Carcinoma

    ZHANG Fan, CHANG Yongxia, ZHANG Jiuhong, et al

    Department of Pathology,the First Affiliated Hospital, Hebei North University,Zhangjiakou,075000,Hebei China

    【ABSTRACT】Objective:To investigate the expression of pglycoprotein(pgp)、glutathionestransferaseπ(GSTπ)、topoisomerase Ⅱ(TOpoⅡ) and thymidylate synthase(TS)and their clinical significance in Cervical Carcinoma.Methods:The expressions of pgp、 TOpoⅡ、GSTπ、TS proteins were detected by immmunohistochemistry method in sixtyfive patients with Cervical Carcinoma who were followed up more than ten years.The relationship between the expression of antidrug proteins and clinical prognosis were analysed.Results:The expression of pgp was associated with lymph node metastasis and histological grading (P<005) ......

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