炎症因子；急性冠脉综合征

急性冠脉综合征患者炎症因子活化水平的临床观察

http://www.100md.com 《吉林医药医学学报》 2006年第3期

炎症因子；急性冠脉综合征,1材料和方法,2结果,3讨论

     摘要：目的探讨急性冠脉综合征患炎症因子水平的变化情况。方法选择70例急性冠脉综合征患者，用ELISA或放免分析法对其血清中C反应蛋白(CRP)、ET1、OXLDL免疫复合物及肿瘤坏死因子α(TNFα)、可溶性血管细胞间粘附分子1(sVCAM1)、白细胞介素1(IL1β)水平进行了测定。并与30例正常对照组比较。结果急性冠脉综合征患者血清CRP、OXLDLIC、IL1β、TNFα及sVCAM1浓度明显升高于正常对照组(P<0.01)。结论急性冠脉综合征患者体内血清有多种细胞因子水平增高，提示炎症与急性冠脉综合征的发病有关。

    关键词：炎症因子；急性冠脉综合征

    Inflammatory factors activation in patients with acute coronary syndrome

    PAN Xingshou, LU Kexing, HUANG Zhaohe, LAN Jingsheng, YUAN Xihua (Angiocardiopathy institute, Youjiang Medical College for Nationalities, Baise, Guangxi, 533000, China)

    Abstract：Objective To investigate the inflammatory factors activation level in patients with acute coronary syndrome. Methods CRP, ET1, OXLDL, TNFα, sVCAM1 and IL1β were detected by ELISA or radioimmunoassay in 70 patients with acute coronary syndrome and 30 controls. Results Serum concentrations of CRP, OXLDLIC, IL1β, TNFα and sVCAM1 in patients with acute coronary syndrome were significantly higher than that in controls(P<0.01). Conclusion The raise of inflammatory factors in the study suggests the relationship between inflammation and acute coronary syndrome. ......

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