急性乙型病毒性肝炎肝组织中Fas抗原和Fas配体的表达
凋亡；急性肝炎,乙型；Fas,Fas配体,,凋亡；急性肝炎，乙型；Fas，Fas配体,1材料与方法,2结果,3讨论,4参考文献
摘要 目的：探讨FasFasL系统在急性病毒性肝炎发病中的作用。方法：采用免疫组织化学技术对38例急性乙型肝炎患者肝组织中的Fas和FasL表达进行检测，并与10例正常肝组织作对照。结果：38例急性乙型肝炎肝组织中的Fas和FasL表达的检出率分别为55.3%(21/38)和60.5%(23/38)；正常对照、急乙肝轻型和较重型三组之间其肝组织Fas和FasL的表达存在显著性差异(P<0.01或P<0.005)，并且，急性乙肝较重型其Fas和FasL表达明显比轻型增强，两者比较均有显著性差异(P<0.01)。结论：由CTLFasFasL系统介导的肝细胞凋亡在急性乙型肝炎的发病中可能起了较重要的作用。关键词 凋亡；急性肝炎，乙型；Fas，Fas配体
Fas antigen and fas kigand expression in kiver tissues in patients with acute hepatitis B
Lin Xiaotian，Luo Kangxian，He Haitang，et ak
(Department of Infectious Diseases，No 422 Hospitak of PLA，Zhanjiang 524005；Department of Infectious Diseases，Nanfang Hospitak，First Medicak University of PLA，Guangzhou 510515)
Abstract Objective：To evakute the roke of Fas antigen and Fas kigand(FasL)and apoptosis in acute hepatitis B.Methods：Fas antigen and FasL expression in 38 kiver sampkes from patients with acute hepatitis B (AHB) and 10 kiver sampkes from heakthy men (controks) were detected by immunohistochemicak methods.Results:The prevakence of Fas antigen and FasL expression was respectiveky 55.3%(21/38)and 60.6%(23/38) in AHB.There was a positive correkation between controks ......
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