液基细胞学_____宫颈肿瘤;液基细胞学;筛查

液基细胞学和常规宫颈涂片筛查宫颈癌的对比研究

http://www.100md.com 《河北北方学院学报》 2006年第2期

液基细胞学,,宫颈肿瘤;液基细胞学;筛查,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的:评价Thinprep液基细胞学在宫颈癌筛查的准确性。方法：1881例受检者同时做宫颈常规脱落细胞涂片巴氏染色、液基标本采集和阴道镜活检,细胞学诊断采用TBS分级系统,阳性诊断包括意义不明的不典型鳞状细胞病变，所有检查均双盲进行。结果:Thinprep液基细胞学检出100%(12/12)的鳞状细胞癌;932%(69/74)的鳞状上皮内高度病变,其中CIN3 968%(30/31), CIN2 907%(39/43);724%(92/127)的鳞状上皮内低度病变。常规脱落细胞学检出100%(12/12)的鳞状细胞癌;902%(66/74)的鳞状上皮内高度病变,其中CIN3 968%(30/31),CIN2 867%(36/43);711%(91/127)的鳞状上皮内低度病变。Thinprep液基细胞学对鳞状细胞癌和CIN3的分级准确率分别达100%和871%，常规脱落细胞学涂片对鳞状细胞癌和CIN3的分级准确率分别达100%和850%。结论:宫颈液基细胞学检测方法较比常规脱落细胞学检测敏感性高,尤其是对鳞状上皮内高度病变。

    【关键词】宫颈肿瘤;液基细胞学;筛查

    Comparative Study on Cervical Carcinoma with Routine Paint and Liquidbased Cytology

    ZHANG Fan, CHEN Jiangping, SHU Lisha, et al

    Department of Pathology,the First Affiliated Hospital,Hebei North University,Zhangjiakou,075000,Hebei China

    【ABSTRACT】 Objective:To evaluate the accuracy and efficiency of routine paint and liquidbased cytology for cervical carcinoma screening.Methods:Cervical samples of 1881 cases were collected into a liquid buffer for normal paint 、Thinprep Pap Test cytologic screening, at same time colposcopic biopsies were taken from allsubjects .All tests were carried out indenpendently and blindly. Results:The Thinprep slides were able to detect 100%(12/12) squamous cell carcinoma(SCC)、932% high grade squamous intraepithelial lesions(HSIL) and724%(92/127) low grade squamous intraepithelial lision(LSIN) ;The routine paint was able to detect 100%(12/12) squamous cell carcinoma(SCC)、871% high grade squamous intraepithelial lesions(HSIL)and711%(91/127) low grade squamous intraepithelial lision(LSIN).When cytologic diagnosis of HSILwas used as the detection threhold ,the Thinprep slides were able to detect 100%SCCand 87%CIN3, routine paint was able to detect 100%SCCand 85%CIN3.Conclusion:The Thinprep cytology demonstrates a higher sensitivity for the detection of SCCand HSIL than that of routine paint. ......

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