中国人群HLA-DRB1基因多态性与慢性乙型肝炎关系的Meta分析
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骆 峻, 金安娜, 吴旭东, 喻荣彬
慢性乙型肝炎;人类白细胞抗原Ⅱ;HLA-DRB1;基因多态性;Meta分析,骆峻,喻荣彬,骆峻,金安娜,吴旭东,通讯作者:
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骆峻, 喻荣彬, 南京医科大学公共卫生学院流行病与卫生统计学系 江苏省南京市 210029
骆峻, 金安娜, 吴旭东, 江苏职工医科大学医学微生物学教研室 江苏省南京市 210029
国家自然科学基金资助课题, No. 30200232
通讯作者: 喻荣彬, 210029, 江苏省南京市, 南京医科大学流行病与卫生统计学系. rongbinyu@njmu.edu.cn
电话: 025-86862815 传真: 025-86527613
收稿日期: 2006-07-23 接受日期: 2006-09-20
Meta-analysis on the relationship between HLA-DRB1 gene polymorphism and chronic hepatitis B in Chinese population
Jun Luo, An-Na Jin, Xu-Dong Wu, Rong-Bin Yu
Jun Luo, Rong-Bin Yu,Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Jun Luo, An-Na Jin, Xu-Dong Wu,Department of Medical Microbiology, Jiangsu Staff Medical University, Nanjing 210029, Jiangsu Province, China
Supported byNational Natural Science Foundation of China, No. 30200232
Correspondence to:Rong-Bin Yu, Department of Epidemiology and Biostatistics, University, Nanjing 210029, Jiangsu Province, China. rongbinyu@njmu.edu.cn
Received:2006-07-23 Accepted:2006-09-20
Abstract
AIM: To assess the associations of HLA-DRB1 gene polymorphism with chronic hepatitis B in Chinese population.
METHODS: A comprehensive search for articles from 1998 to 2006 was conducted from Chinese BioMedical Literature Database on disc (CBMdisc), VIP and Medline databases. A total of 8 epidemiological case-control studies on the relationship between gene polymorphism of HLA-DRB1 and chronic hepatitis B were performed and the results were analyzed using RevMan 4.2 software.
RESULTS: A total of 501 patients with chronic hepatitis B and 855 uninfected healthy controls were included from the 8 studies. HLA-DRB1*03 and HLA-DRB1*08 alleles were the risk factors of CHB, the values of pooled odds ratio were 2.44 (95%CI: 1.65-3.61, P < 0.00001) and 1.57 (95%CI: 1.08-2.28, P = 0.02), respectively. HLA-DRB1*13 and HLA-DRB1*15 alleles were the protection factors against CHB, and the values of pooled odds ratio were 0 ......
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