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编号:11319619
胃癌组织中转化生长因子α、表皮生长因子受体和增殖细胞核抗原的表达
http://www.100md.com 王春虹, 刘丽娜, 吕 申
转化生长因子α;表皮生长因子受体;增殖细胞核抗原;胃癌,王春虹,刘丽娜,吕申,王春虹,通讯作者:,Expression
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     王春虹, 本溪市本钢总医院消化内科 辽宁省本溪市 117000

    刘丽娜,
大连医科大学附属一院消化内科 辽宁省大连市 116011

    吕申,
大连医科大学附属二院中心实验室 辽宁省大连市 116023

    王春虹,
2005年大连医科大学硕士, 副主任医师, 主要从事胃癌病理与临床的研究.

    通讯作者:
王春虹, 117000, 辽宁省本溪市, 本溪市本钢总医院消化内科. chunhong1970@126.com

    电话: 0414-2215138

    收稿日期: 2006-05-31 接受日期: 2006-09-01

    Expression of transforming growth factor-α, epidermal growth factor receptor and proliferating cell nuclear antigen in human gastric cancer tissues

    
Chun-Hong Wang, Li-Na Liu, Shen Lv

    Chun-Hong Wang,
Department of Gastroenterology, General Hospital, Bengang Iron and Steel Corporation, Benxi 117000, Liaoning Province, China

    Li-Na Liu,
Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China

    Shen Lv,
Center Laboratory, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province

    Correspondence to:
Chun-Hong Wang, Department of Gastroenterology, General Hospital, Bengang Iron and Steel Corporation, Benxi 117000, Liaoning Province, China. chunhong1970@126.com

    Received:
2006-05-31 Accepted:2006-09-01

    Abstract

    AIM: To observe the expression of transforming growth factor-α (TGF-α), epidermal growth factor receptor (EGFR) and proliferating cell nuclear antigen (PCNA) as well as their correla-tions in gastric carcinoma.

    METHODS: Immunohistochemical staining (SP method) was used to detect the expression of TGF-α, EGFR and PCNA in specimens from 62 gastric carcinoma patients, and the pathological characteristics were comparatively analyzed.

    RESULTS: The positive rates of TGF-α, EGFR and PCNA expression in normal gastric mucosa were significantly lower than those in gastric carcinoma (χ2 = 10.090, P < 0.05; χ2 = 4.373, P < 0.05; χ2 = 31.230, P < 0.05), while their positive expression rate were markedly higher in the lowly-differentiated adenocarcinoma and mucosal carcinoma than those in the highly- and moderately-differentiated one (χ2 = 15 ......

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