脑梗死；_依达拉奉；_TNFα；_IL8_

依达拉奉对脑梗死患者血清中TNFα和IL8影响

http://www.100md.com 《第四军医大学学报》 2006年第19期

脑梗死；,依达拉奉；,TNFα；,IL8,,脑梗死；,依达拉奉；,TNFα；,IL8,0引言,1对象和方法,2结果,3讨论,【参考文献

     WANG ZhaoHui, LI BaoPing

    Department of Neurology, Huaihe Hospital,Henan University, Kaifeng 475000, China

    【Abstract】 AIM: To explore the effect of edaravone on the serum levels of TNFα and IL8 in patients with cerebral infarction. METHODS: A total of 82 cases with cerebral infarction were divided randomly into control group (40 cases) and edaravone group (42 cases). All cases were given routine treatment, and the edaravone group were added with edaravone 30 mg, twice daily for 14 d IVGTT. The serum levels of TNFα and IL8 and clinical outcome were investigated before and 15 d after treatment. RESULTS: The therapeutic efficacy (86.49%) of edaravone group 15 d after treatment was significantly better than that of control group (62.86%, P<0.01), and the serum levels of TNFα and IL8 in the edaravone group were lower than those of control group [TNFα (ng/L) 6.3±1.3 vs 10.2±3.0, IL8 (ng/L) 10.2±3.0 vs 100.3±34.5, P<0.01]. CONCLUSION: Edaravone can reduce the injury of ischemic brain and improve therapeutic efficacy, probably by inhibiting the production of TNFα and IL8 and stopping the leukocytes from infiltrating into ischemic region. ......

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