慢传输型便秘患者结肠中五羟色胺受体亚型的表达及意义
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丁健华, 赵荣华, 傅传刚, 毕丽霞, 孟荣贵,
五羟色胺;五羟色胺受体;慢传输型便秘;免疫组化丁健华,赵荣华,傅传刚,毕丽霞,孟荣贵.慢传输型便秘结肠中五羟色胺受体亚型的表达及其意义. 世界华人消化杂志2006;14(32)3111-3
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丁健华, 傅传刚, 孟荣贵, 喻德洪, 第二军医大学长海医院肛肠外科 上海市 200433
赵荣华, 美国克利福兰基金会佛罗里达医院肛肠外科 美国佛罗里达州 33331
毕丽霞, 中国人民解放军第二炮兵总医院肛肠外科 北京市 100088
丁健华, 男, 1975-10-04生, 上海市人, 汉族, 2006年上海第二军医大学博士毕业, 现在北京第二炮兵总医院肛肠外科、全军肛肠病专病中心, 主治医师, 主要从事胃肠道肿瘤及功能性疾病研究.教育部留学回国人员科研启动基金课题, 教外司留[2001]345号
通讯作者: 丁健华, 200433, 上海市, 第二军医大学长海医院肛肠外科. junyi93@yahoo.com.cn
电话: 021-25072073
收稿日期: 2006-06-14 接受日期: 2006-09-01
Expression of serotonin receptor subtypes and its significance in the colon of patients with slow transit constipation
Jian-Hua Ding, Rong-Hua Zhao, Chuan-Gang Fu, Li-Xia Bi, Rong-Gui Meng, De-Hong Yu
Jian-Hua Ding, Chuan-Gang Fu, Rong-Gui Meng, De-Hong Yu, Department of Colorectal Surgery, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
Rong-Hua Zhao, Department of Colorectal Surgery, Cleveland Clinic, Florida 33331, the United States
Li-Xia Bi, Department of Colorectal Surgery, General Hospital of the Second Artillery of Chinese PLA, Beijing 100088, China
Supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, No. [2001]345
Correspondence to: Jian-Hua Ding, Department of Colorectal Surgery, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China. junyi93@yahoo.com.cn
Received: 2006-06-14 Accepted: 2006-09-01
Abstract
AIM: To investigate the expression of serotonin receptor subtypes in the colon of patients with slow transit constipation (STC), and explore its role in the pathogenesis of STC.
METHODS: Using Envision immunohistochemical staining, we detected the expression and distribution of 5-HT1A receptor, 5-HT3 receptor and 5-HT4 receptor in the colon of 20 STC patients and 20 controls. IMS computer analysis system was used for semi-quantitative analysis.
RESULTS: 5-HT1A receptor was positively scattered in submucosa and muscular layer ......
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