HBeAg阴性和阳性慢性乙型肝炎患者血清HBV DNA水平与肝组织炎症的关系
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李仕周, 蒋永芳
乙型肝炎,HBVDNA,肝组织炎症,HBeAg阴性和阳性慢性乙型肝炎患者血清HBVDNA水平与肝组织炎症的关系,李仕周,蒋永芳,通讯作者:,Relationshipbetweenliverpa
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李仕周, 湖南省郴州市第一人民医院消化内科 湖南省郴州市 423000
蒋永芳, 中南大学湘雅二医院肝病研究中心 湖南省长沙市 410011
通讯作者: 李仕周, 423000, 湖南省郴州市, 湖南省郴州市第一人民医院消化内科. bill-jdf@263.net
收稿日期: 2006-09-11 接受日期: 2006-09-25
Relationship between liver pathologic histology and levels of serum hepatitis B virus DNA in patients with HBeAg-positive and -negative chronic hepatitis B
Shi-Zhou Li, Yong-Fang Jiang
Shi-Zhou Li,Department of Internal Medicine, the First People’s Hospital of Chenzhou City, Chenzhou 423000, Hunan Province, China
Yong-Fang Jiang,Center for Liver Disease, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
Correspondence to:Shi-Zhou Li, Department of Internal Medicine, the First People’s Hospital of Chenzhou City, Chenzhou 423000, Hunan Province, China. bill-jdf@263.net
Received:2006-09-11 Accepted:2006-09-25
Abstract
AIM: To investigate the relationship between serum hepatitis B virus (HBV) DNA levels and the inflammatory degrees of liver tissues in patients with HBeAg-positive and -negative chronic hepatitis B.
METHODS: HBV DNA level was assayed by fluorescent quantitative polymerase chain reaction (FQ-PCR) in 331 patients (230 HBeAg positive and 101 HBeAg negative). Liver biopsy was performed and the grading and staging of liver tissues were routinely obtained.
RESULTS: There was not obvious correlation between serum HBV DNA level and the grading and staging of liver tissues in 331 patients with chronic hepatitis B. Of the 101 patients with negative HBeAg, 31 cases were with more than 108 copies/L HBV DNA, and there was significant correlation between HBV DNA level and the grading of tissues (r = 0.271, P < 0.005). A significant inverse correlation was demonstrated between HBV DNA level and hepatitis activity in the 230 patients with positive HBeAg (r = -0 ......
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