HSP70, HSP90在结肠癌中表达及其和生物学行为的相关性
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陈 怡, 冉志华, 陈 翔, 朱长清, 萧树东
结肠癌;热休克蛋白70;热休克蛋白90;生物学行为,HSP70,HSP90在结肠癌中表达及其和生物学行为的相关性,陈怡,冉志华,陈翔,萧树东,陈怡,朱长清,陈怡,通讯作者:,Express
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陈怡, 冉志华, 陈翔, 萧树东, 上海交通大学医学院附属仁济医院消化科 上海市消化疾病研究所 上海市 200001
陈怡, 朱长清, 上海交通大学医学院附属仁济医院急诊科 上海市 200127
陈怡, 2006年上海交通大学医学院消化专业硕士, 主治医生.
上海市重点学科建设项目资助, No. Y0205
通讯作者: 冉志华, 200001, 上海市, 上海交通大学医学院附属仁济医院消化科, 上海市消化疾病研究所. z-ran@online.sh.cn
电话: 021-58752345 传真: 021-63266027
收稿日期: 2006-09-28 接受日期: 2006-10-11
Expression of heat shock protein 70 and 90 and their relationships with biological behaviors of colon cancer
Yi-Chen, Zhi-Hua Ran, Xiang-Chen, Chang-Qing Zhu, Shu-Dong Xiao
Yi-Chen, Zhi-Hua Ran, Xiang-Chen, Shu-Dong Xiao,Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine; Shanghai Institute of Digestive Diseases, Shanghai 200001, China
Yi-Chen, Chang-Qing Zhu,Department of Emergency Management, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
Supported byShanghai Leading Academic Discipline Project, No. Y0205
Correspondence to:Dr. Zhi-Hua Ran, Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine; Shanghai Institute of Digestive Diseases, Shanghai 200001, China. z-ran@online.sh.cn
Received:2006-09-28 Accepted: 2006-10-11
Abstract
AIM: To investigate the expression of heat shock protein (HSP) 70 and 90 as well as their correlations with the biological behavior of colon cancer.
METHODS: Specimens were collected from the cancerous lesions, paracancerous tissues (2 cm away from cancer lesion) and normal mucosal tissues of 40 patients with colon cancer after colon resection. The expression of HSP70 and HSP90 were detected using affinitive immunohistochemical technique. Meanwhile, Duke’s staging for the 40 colon cancer patients was analyzed, and the relationship between the expression levels of HSPs and Duke’s staging was further investigated.
RESULTS: The levels of HSP70 and HSP90 expression between the cancerous tissues, paracancerous tissues, and normal tissues (HSP70: 82 ......
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