[摘要] [目的] 探讨黄芪对高脂血症小鼠血脂及脂质过氧化的影响. [方法] 取小鼠随机分组，除正常组外的其他组小鼠灌胃给予脂肪乳剂，建立高脂血症小鼠模型，分别灌胃给予不同剂量黄芪组小鼠18.0，9.0，4.5g/kg黄芪水提取物，连续4周，测定各组小鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)含量，谷胱甘肽过氧化物酶(GSH-Px)和超氧化化物歧化酶(SOD)活性，脂质过氧化物(LPO)含量. [结果] 不同剂量黄芪组小鼠血清TC，TG，LDL-C含量明显下降，SOD，GSH-Px活性明显增强，血清LPO含量明显下降. [结论] 黄芪具有调节小鼠血脂代谢及增强机体抗脂质过氧化的作用.

    [关键词] 高脂血症;过氧化脂质;植物，药用

    Effects of Astragalus on serum lipids and lipoperoxidation in experimental hyper lipidemic mice

    JIN Guang-xian 1 ，ZHANG Xue-wu 2*

    (Department of Pathology and Forensic Medicine;Department of Biochemistry and Molecular Biology:Yanbian University College of Basic Medicine，Yanji133000，Jilin，China)

    ABSTRACT:OBJECTIVE To investigate the effects of Astragalus on serum lipids and lipoperoxidation in experimental hyperlipidemic mice.METHODS The mice were randomly divided ......