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吗替麦考酚酯联合泼尼松治疗难治性狼疮性肾炎的疗效观察
http://www.100md.com 《第四军医大学学报(新)》 2006年第20期
吗替麦考酚酯;狼疮肾炎;疗效,,吗替麦考酚酯;狼疮肾炎;疗效,1对象和方法,2结果,3讨论,【参考文献】
     DU JuanLi1, WANG HanMin2, LIAN YaoGuo2, YU Yan2, CHEN Wei2, LIU XiaoWei2

    1Department of Internal Medicine, Xian Fifth Hospital, Xian 710082, China, 2Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the effect and the side effects of mycophenolate mofetil(MMF) combined with prednisone in the treatment of refractory lupus nephritis. METHODS: Fortytwo patients who had been nonresponsive to conventional immunosuppressor or suffered from recrudescent infection were cure by MMF combined with prednisone. The clinical curative effect and the levels of active markers were examined before treatment and 3, 6, 12 month after treatment. RESULTS: ① After 3month treatment, complete remission was achieved in 33%, partial remission in 24%. After 6 months, the proportion was raised to 38% and 26%, respectively. After 12 months, it was raised to 50% and 31%, respectively.The total efficiency was 81%. ② Compared with the data before treatment, 24 h urinary protein, urine IL6, the serum Creactive protein, ESR, antidsDNA antibody and antinucleus antibody were significantly decreased after 3 months, and further with the ongoing treatment. The albumin and complement C3 were significantly increased after 3 months, and increasingly with the extending time of treatment. ③ Side effects of MMF were very few, and the safety and tolerance were good. CONCLUSION: MMF combined with prednisone can improve the active indexes of refractory lupus nephritis and is of better tolerance and safety,as well as very few side effects. ......

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