Celecoxib对胃癌细胞凋亡的影响
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凌桂琴, 王 绪, 王 琳, 李小翠
胃癌;Celecoxib;细胞凋亡凌桂琴,王绪,王琳,李小翠.Celecoxib对胃癌细胞凋亡的影响. 世界华人消化杂志2006;14(34)3302-3305,Celecoxib对胃癌细
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凌桂琴,徐州医学院第二附属医院肿瘤内科 江苏省徐州市 221006
王绪,徐州医学院医学影像学系 江苏省徐州市 221002
王琳,徐州医学院组胚教研室 江苏省徐州市 221002
李小翠,徐州医学院微生物学教研室 江苏省徐州市 221002
通讯作者:凌桂琴, 221006, 江苏省徐州市, 徐州医学院第二附属医院肿瘤内科. lingguiqin@126.com
收稿日期:2006-08-02 接受日期: 2006-09-29
Effect of Celecoxib on apoptosis of human gastric cancer cell line
Gui-Qin Ling, Xu Wang, Lin Wang, Xiao-Cui Li
Gui-Qin Ling, Department of Oncology, the Second Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, Jiangsu Province, China
Xu Wang, Department of Radiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China
Lin Wang, Department of Histology and Embryology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China
Xiao-Cui Li, Department of Microbiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China
Correspondence to: Gui-Qin Ling, Department of Oncology, The Second Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, Jiangsu Province,China. lingguiqin@126.com
Received: 2006-08-02 Accepted: 2006-09-29
Abstract
AIM: To explore the effect of Celecoxib (cyclooxygenase-2 inhibitor) on the apoptosis of gastric cancer cell line SGC7901 in vitro.
METHODS: After gastric cancer cell line SGC7901 was treated with Celecoxib (1×10-5 to 1 ×10-9 mol/L) for 24 hours, the proliferration of cells was detected by MTT assay. Flow cytometry (FCM) was used to measure the apoptosis of SGC7901 cells, and immunocytochemistry was used to observe the expression of Survivin.
RESULTS:Celecoxib inhibited the proliferation of SGC7901 cells at the concentrations of 1×10-5 to 1×10-9 mol/L, and the maximal inhibitory rate was 30 ......
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