蛋白酶激活受体-2激动剂在应激性溃疡中的作用
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窦勇鹰, 谢立群, 李俊美, 华建平, 海 鸥,
蛋白酶激活受体-2;应激性溃疡;胃黏膜;辣椒素窦勇鹰,谢立群,李俊美,华建平,海鸥,李华.蛋白酶激活受体-2激动剂在应激性溃疡中的作用. 世界华人消化杂志2006;14(34)3306-3
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窦勇鹰, 谢立群, 海鸥, 李华,中国人民武装警察部队医学院附属医院消化内科 天津市河东区 300162
李俊美, 华建平,天津市第一中心医院消化内科 天津市 300192
通讯作者:谢立群, 天津市河东区成林路, 中国人民武装警察部队医学院附属医院消化内科. xieliqun66@hot.mail
电话:022-60578765
收稿日期:2006-07-20 接受日期:2006-08-10
Role of protease-activated receptor-2 agonist in the formation of stress ulcer
Yong-Ying Dou, Li-Qun Xie, Jun-Mei Li, Jian-Ping Hua, Ou Hai, Hua Li
Yong-Ying Dou, Li-Qun Xie, Ou Hai, Hua Li, Department of Gastroenterology, the Affiliated Hospital of Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China
Jun-Mei Li, Jian-Ping Hua, Department of Gastroenterology, the First Center Hospital of Tianjin Municipality, Tianjin 300192, China
Correspondence to: Li-Qun Xie, Department of Gastroenterology, the Affiliated Hospital of Medical College of Chinese People's Armed Police Forces, Chenglin Road, Hedong District, Tianjin 300162, China. xieliqun66@hot.mail
Received: 2006-07-20 Accepted: 2006-08-10
Abstract
AIM: To investigate the role of protease-activated receptor-2 (PAR-2) agonist in the formation and pathogenesis of stress ulcer.
METHODS:Water immersion-restaint method was used to induce stress ulcer model in Wistar rats. Arterial blood and gastric fluid were colleted for the blood gas analysis to obtain the gastric mucosal pH value. The levels of thromboxane B2 (TXB2) and 6-ketoprostaglandin F1 alpha (6-K) were measured by radioimmunoassay. The content of mucosal aminohexose was detected by spectro photometer, and the histopathological changes were observed.
RESULTS:The gastric mucosal pH value (4.71 ± 0.23 vs 4.53 ± 0.11, P < 0.05), the content of mucosal aminohexose (5.26 ± 1.48 g/kg vs 1.19 ± 0.58 g/kg, P < 0.05), and the level of 6-K (856.92 ± 165.21 ng/L vs 654.50 ± 221 ......
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