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萎缩性胃炎大鼠胃黏膜主、壁细胞和G、D细胞及外周血胃泌素、生长抑素的变化
http://www.100md.com 朱方石, 姒健敏, 王良静, 王冬飞, 陈 萍
萎缩性胃炎;主细胞;壁细胞;G细胞;D细胞;胃泌素;生长抑素;大鼠朱方石,姒健敏,王良静,王冬飞,陈萍.萎缩性胃炎大鼠胃黏膜主、壁细胞和G、D细胞及外周血胃泌素、生长抑素的变化. 世界华人
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     朱方石, 江苏省中医药研究院消化病研究室 江苏省南京市 210028

    姒健敏,
王良静, 王冬飞, 陈萍, 浙江大学邵逸夫临床医学研究所 浙江省杭州市 310016

    朱方石,
临床医学博士, 浙江大学临床医学博士后流动站出站博士后, 副教授, 副主任医师,硕士生导师, 主要从事胃肠病的中西医结合临床及基础研究.

    中国博士后科学基金资助项目, No. 2002032232

    通讯作者:
朱方石, 210028, 江苏省南京市红山路十字街100号, 江苏省中医药研究院消化病研究室. zhufs@tom.com

    电话:
025-51779122 传真: 025-85637817

    收稿日期:
2006-08-21 接受日期: 2006-09-27

    Changes of gastric mucosal chief and parietal cells and G, D cells as well as blood gastrin somatostaitin levels in rats with chronic atrophic gastritis

    Fang-Shi Zhu, Jian-Min Si, Liang-Jing Wang, Dong-Fei Wang, Ping Chen

    Fang-Shi Zhu, Department of Digestive Diseases, Jiangsu Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, China

    Jian-Min Si, Liang-Jing Wang, Dong-Fei Wang, Ping Chen,
Sir Run Run Shaw Clinical Medical Institute of Zhejiang University, Hangzhou 310016, Zhejiang Province, China

    Supported by
the Postdoctoral Scientific Foundation of China, No. 2002032232

    Correspondence to:
Dr. Fang-Shi Zhu, Department of Digestive Diseases, Jiangsu Academy of Traditional Chinese Medicine, 100 Shizijie of Hongshan Road, Nanjing 210028, Jiangsu Province, China. zhufs @tom.com

    Received:
2006-08-21 Accepted: 2006-09-27

    Abstract

    AIM:
To study the changes of chief, parietal cells and G, D cells in gastric mucosa as well as blood levels of gastrin (GAS) and somatostaitin (SS) in chronic atrophic gastritis (CAG) rats, and explore the possible mechanism of CAG generation.

    METHODS: The rat models of CAG were made with 1 mL/L ammonia water, 20 mmol/L sodium deoxycholate and 600 mL/L ethanol, and the histopathological changes of gastric mucosa were observed. Pathological method and immunohistochemical staining were used to investigate the changes of chief, parietal cells and G, D cells in gastric mucosa and measure the blood levels of GAS and SS in CAG rats ......

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