利多卡因；_芬太尼；_咳嗽_____利多卡因；

静脉注射利多卡因抑制芬太尼所致咳嗽反应的临床观察

http://www.100md.com 《新疆医科大学学报》 2006年第11期

利多卡因；,芬太尼；,咳嗽,,利多卡因；,芬太尼；,咳嗽,1资料与方法,2结果,3讨论,参考文献：

     摘要：目的：观察静脉预先注射利多卡因对全麻诱导期间不同剂量芬太尼所致咳嗽反应的抑制作用。方法：64例需全身麻醉下行择期手术的患者，随机分为利多卡因Ⅰ组(利多卡因1.5 mg/kg+芬太尼3 μg/kg )、Ⅱ组(利多卡因1.5 mg/kg+芬太尼5 μg/kg)和对照Ⅰ组(生理盐水5 ml+芬太尼3 μg/kg)、Ⅱ组(生理盐水5 ml+芬太尼5 μg/kg)，观察4组芬太尼注射后的咳嗽发生率及程度。结果：对照Ⅰ组和Ⅱ组患者的咳嗽发生率分别为43.75%和62.5%，利多卡因Ⅰ、Ⅱ组静脉预先注射利多卡因1.5 mg/kg后，芬太尼诱导的咳嗽发生率分别降低至18.8%和31.2%，明显低于对照Ⅰ、Ⅱ组，差异均有统计学意义(P<0.05)。结论：预先静脉注射利多卡因可有效降低麻醉诱导期间芬太尼所致咳嗽的发生率。

    关键词：利多卡因；芬太尼；咳嗽

    Clinical observation on intravenous lidocaine suppresses fentanylinduced coughing

    LI Yan, CHEN Lin, ZHU Sujie, et al

    (Department of Anesthesiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, China)

    Abstract: Objective: To observe the effect of prophylactic intravenous administration of lidocaine against fentannyl induced coughing during anesthesia induction. Methods: Sixtyfour patients of ASA physical status I and II scheduled for elective surgery were randomly allocated to one of four groups of sixteen patients. Each to receive either lidocaine 1.5 mg/kg or placebo (0.9% saline) before the administration of fentanyl 3 μg/kg or 5 μg/kg. Coughs classified as coughing and graded as mild, moderate, or severe and were recorded. Results: Intravenous lidocaine 1.5 mg/kg, when administered before fentanyl (3 μg/kg or 5 μg/kg), was significantly effective in suppressing fentanylinduced cough compared to placebao (P<0.05). Conclusions: The prophylactic injection of lidocaine is efficient in attenuating fentanylinduced cough rate during anesthesia induction. ......

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