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编号:11315800
老年脑卒中患者血浆ACE水平及其基因多态性的研究
http://www.100md.com 《实用老年医学》 2006年第5期
脑血管意外;,肽基二肽酶A;,老年人,1对象与方法,2结果,3讨论,参考文献
     【摘要】 目的 探讨老年脑卒中患者血管紧张素转换酶(ACE)基因插入/缺失多态性与其血浆ACE水平的关系。 方法 应用多聚酶链反应(PCR)方法检测ACE基因多态性,同时用比色法测定血清ACE水平。对50例老年脑卒中患者与50例老年健康对照者进行比较分析。 结果 老年脑卒中组D等位基因频率显著高于对照组(P<005), DD基因型患者血清ACE水平亦显著高于对照组(P<005)。 结论 血浆ACE水平和ACE基因多态性有关,提示D等位基因可能与老年脑卒中的危险因素有关。

    【主题词】 脑血管意外; 肽基二肽酶A; 老年人

    Study of ACE gene polymorphism and serum ACE level in elderly patients with cerebral stroke ZENG Aiping .Department of Geriatrics,the 454th Hospital of PLA ,Nanjing 210002 China; MA Jianfang .Department of Geriatrics of Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350002 China

    【Abstract】 Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and serum ACE level in elderly patients with cerebral stroke. Methods Polymerase chain reaction(PCR) was used to examine ACE gene polymorphism. The distribution of three ACE genotypes frequencies and D allele frequency in 50 elderly patients with cerebral strokes were compared with those in 50 healthy controls, whose serum ACE levels were measured with colorimetric technique. Resukts The frequency of D allele was higher in the stroke group than that in healthy controls (P<005).A significant difference in serum ACE level of DD genotype was observed between the stroke group and control group (P<005). Conckusions Serum ACE level was associated with ACE gene I/D polymorphism. It suggests that D allele might be a genetic risk factor for stroke in the elderly. ......

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