冠状动脉疾病；_胆红素；_高脂血症；

老年人血清胆红素与冠心病相关分析

http://www.100md.com 《实用老年医学》 2006年第3期

冠状动脉疾病；,胆红素；,高脂血症；,老年人,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的探讨老年人血清胆红素与冠状动脉病变的关系。方法对符合条件的经冠脉造影确诊的老年冠心病患者135例，测定血清总胆红素、直接胆红素、血脂水平及冠状动脉狭窄程度进行Gensini评分，并分为4组(A～D)，A组(0分)；B组(1～20分)；C组(21～40分)；D组(>40分)。结果冠心病组血清胆红素水平明显低于对照组(P<001)，且随着冠状动脉狭窄程度的加重，血清胆红素水平逐渐下降。相关分析结果显示，血清总胆红素、直接胆红素与血浆总胆固醇、三酰甘油、低密度脂蛋白胆固醇均呈负相关，与高密度脂蛋白胆固醇呈正相关。Logistic回归分析表明血清总胆红素与冠心病呈独立负相关(OR=0913，P<005)。结论血清胆红素是冠心病一项独立的危险因素。

    【主题词】冠状动脉疾病；胆红素；高脂血症；老年人

    Relationship between the level of serum bilirubin and the severity of coronary lesion in the elderly QIN Yanqiong，LIU Changhui.Department of Geriatrics,Peoples Hospital of Wuhan University,Wuhan 430060 China

    【Abstract】 Objective To explore the relationship between the severity of coronary artery lesion and the level of serum bilirubin in the elderly. Methods 135 elderly patients undergoing coronary angiography were divided into 4 groups according to Gensini score:A(0);B(1～20);C(21～40);D(>40). Resukts The levels of TBIL and IBIL in CHD Group were significantly lower than those in control group(P<001) .The total bilirubin concentration of groups B,C and D gradually decreased.There was significant negative correlation between the serum levels of TBIL, IBIL and the serum levels of TC,TG,LDLC.There was positive correlation between the serum level of bilirubin and the serum level of HDLC.Independent negative correlation existed between serum bilirubin and the coronary artery disease. Conckusions The serum bilirubin may be a risk factor of coronary artery disease. ......

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