Treatment effect of metformin on clomipheneª²resistant patients with polycystic ovary syndrome

    HOU Lingª²Tong, TIAN Qingª²You, HAN Suª²Xin, ZHANG Rongª²Hua

    Department of Obstetrics and Gynecology, Affiliated Hospital, Faculty of Basic Medicine, North China Coal Medical College, Tangshan 063000, China

    ¡¾Abstract¡¿ AIM: To observe the treatment effect of metformin(MTF)on clomiphene (CC)ª²resistant infertile patients with polycystic ovary syndrome (PCOS). METHODS: Among 22 CCª²resistant patients with POCS, 20 patients showed insulin resistance (IR). They firstly received MTF threapy for 3 months, later those who failed to conceive received MTF and CC threapy for another 3 months. At the end, the patients¬ð sexual hormone, body mass index (BMI), fasting insulin (I0), 2ª²hour glucose to insulin ratio (G120/I120) and Homeostatic model assessmentª²insulin resistance index (HOMAª²IR) were detected again and the results were compared with those of preª²treatment. At the same time, the ovulation and pregnancy rates were calculated. RESULTS: At the end of 6ª²month MTF treatment on 20 CCª²resistant patients, 12 cases (60%) resumed their ovulation, 10 cases (50%) achieved pregnancy and did not abort. In the 8 patients who did not resume ovulation, however, the level of LH, LH/FSH, BMI, I0, G120/I120 and HOMAª²IR decreased significantly as compared with those of preª²treatment (P<0.05). CONCLUSION: CCª²resistant infertile women with PCOS are mostly associated with IR. MTF treatment is an economic and easily performed method which can be used to improve the ovulation and pregnancy rates. ......