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2型糖尿病微量白蛋白尿与颈动脉内膜中层厚度的关系
http://www.100md.com 《福建医科大学学报》 2006年第5期
白蛋白尿;,颈动脉;,动脉硬化;,血管内膜;,2型糖尿病;,高血压,,白蛋白尿;,颈动脉;,动脉硬化;,血管内膜;,2型糖尿病;,高血压,1对象
     摘要: 目的 探讨2型糖尿病微量白蛋白尿(MAU)与亚临床动脉粥样硬化的关系。 方法 测定74例2型糖尿病病人的24 h尿白蛋白排泄率(UAER)和颈动脉内膜中层厚度(CIMT),根据血压、体质量指数(BMI)和年龄分组,取UAER的对数值(lgUAER)与CIMT进行相关分析。 结果 MAU者CIMT为(1.15±0.38)mm,正常白蛋白尿者为(0.89±0.24)mm,MAU者CIMT明显增厚(P<0.05)。MAU者年龄、BMI、收缩压(SBP)、舒张压(DBP)及脉压差(PP)亦明显增高(P<0.05)。UAER与CIMT、年龄、BMI、SBP、DBP、PP正相关(相关系数分别是0.28,0.35,0.25,0.36,0.25,0.33,P<0.05)。分别校正了年龄、血压和BMI因素后,仅高血压的2型糖尿病患者UAER与CIMT相关(相关系数为0.44,P<0.05)。 结论 2型糖尿病MAU在一定程度上可提示亚临床动脉粥样硬化,但仅是高血压等多种心血管危险因子聚集的反映。

    关键词: 白蛋白尿; 颈动脉; 动脉硬化; 血管内膜; 2型糖尿病; 高血压

    The Relationship between Microalbuminuria and

    Carotid Intimamedia Thickness in Type 2 Diabetic Patients

    Su Yana, Shi Yaxiong

    The Affiliated Second Hospital, Fujian Medical University, Quanzhou, 362000, China

    ABSTRACT: Objective To evaluate the relationship between microalbuminuria and carotid atherosclerosis in type 2 diabetic patients. Methods Urinary albumin excretion rate(UAER) and carotid intimamedia thickness(CIMT) were measured in 74 cases of type 2 diabetic patients. The association between UAER and CIMT were studied. Results CIMT in subjects with microalbuminuria and normalbuminura were (1.15±0.38)mm and (0.89±0.24)mm respectively(P<0.05). Subjects with microalbuminuria have higher age, BMI, systolic blood pressure(SBP), diastolic blood pressure(DBP) and pulse pressure(PP)(P<0.05). UAER was positively correlated with CIMT, age, BMI, SBP, DBP and PP, with the correlation coefficient 0.28, 0.35, 0.25, 0.36, 0.25 and 0.33, respectively(P<0.05). After adjustment of age, blood pressure and BMI, UAER was associated with CIMT only in hypertensive group, with the correlation coefficient 0.44(P<0.05). Conclusion Microalbuminuria can imply subclinical atherosclerosis to some extent. ......

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