肿瘤标记物放射免疫测定与18F-FDG符合线路显像/CT和CT显像在肿瘤诊断中应用分析
18F-FDG；符合线路显像；体层摄影术,X线计算机；肿瘤标记物,,],18F-FDG；符合线路显像；体层摄影术，X线计算机；肿瘤标记物,肿瘤标记物放射免疫测定与18F-FDG符合线路显像,CT
[摘要] 目的 对比研究肿瘤标记物放射免疫测定、CT和18F-FDG符合线路(DHC/CT)肿瘤代谢显像在肿瘤诊断上的价值。方法 选择确诊或疑似恶性肿瘤的患者95例，均进行肿瘤标记物(αFP、CEA、CA50、CA125、CA153、CA211)放射免疫测定、螺旋CT检查和18F-FDG符合线路(DHC/CT，Hawkeye，1吋NaI晶体)肿瘤代谢显像，并对检查的结果进行对比分析。结果 95例患者中最后确诊为恶性肿瘤85例，其中18F-FDG检查发现显像阳性83例，灵敏度为95.29%(81/85)，其中假阳性2例，阳性预测值97.59%(81/83)，显像阴性者12例，其中假阴性4例，特异性为80.00%(8/10)，阴性预测值66.67%(8/12)。临床诊断、肿瘤标记物放射免疫测定、CT显像的检查和18F-FDG DHC/CT显像结果相一致的有56例(58.94%)、不一致的有39例(41.05%)，其中临床诊断与18F-FDG检查结果相一致的有91例(95.79%)、不一致的有4例(4.21%)。结论 作为体检筛选肿瘤病例来讲，肿瘤标记物放射免疫测定的检测较CT显像和18F-FDG DHC/CT显像方便和简捷，而且费用较低。CT和18F-FDG DHC-SPECT/CT显像，其灵敏度和阴性预测值较肿瘤标记物放射免疫测定像均有所提高；CT和PET等肿瘤代谢显像在肿瘤诊疗中各有其优势和不足，临床实践显示两者不是取代而是互补。结合我国的国情，18FDG DHC-SPECT/CT在肿瘤诊疗中有一定实用性。[关键词] 18F-FDG；符合线路显像；体层摄影术，X线计算机；肿瘤标记物
Comparison of tumor marker radioimmunoassay,18F-FDG coincidence imaging and CT imaging in diagnosis of tumors
WANG Ying,JIN Yao-ge,LIN Jia-cheng.Department of Nuclear Medicine,Xuhui Central Hospital,Shanghai 200031,China
[Abstract] Objective To assess the value of tumor marker radioimmunoassay,CT and 18F-FDG(DHC/CT)coincidence tumor metabolism imaging in the detection of tumor.Methods 18F-FDG coincidence tumor metabolism imaging (DHC/CT,Hawkeye)was performed on 95 patients with documented or suspected malignant tumor.The results of 18F-FDG imaging were compared with that of tumor marker radioimmunoassay (αFP,CEA,CA50,CA125,CA153,CA211)and spiral CT.Results 85 of 95 patients were finally diagnosed as malignant tumor.The sensitivity,specificity,positive predict value and negative predict value of 18F-FDG coincidence tumor metabolism imaging were 95.29%(81/85),80.00%(8/10),97.59%(81/83)and 66.67%(8/12)respectively,there were 2 false positive,4 false negative.The results 18F-FDG DHC/CT imaging had good in accordance with that of tumor marker radioimmunoassay and CT studies in 56 patients (58.94%),while inconsistent in 39(41.05%) patients.Conclusion As a tumor screening examination,tumor marker radioimmunoassay compared with the CT imaging and 18F-FDG DHC/CT is more convenient and simpler,and moreover the expense is lower.The sensitivity and negative predict value of CT and 18F-FDG DHC-SPECT/CT imaging is higher than tumor marker radioimmunoassay.CT imaging and 18F-FDG DHC/CT have their own advantage and disadvantage,thus they are complimentary.18F-FDG DHC-SPECT/CT imaging is an effective method for detection,staging and predicting prognosis of these patients with tumor.Considering our countrys condition,18F-FDG DHC SPECT/CT imaging in oncology has its certain practicality. ......
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