腹腔镜胆囊切除术对细胞因子、内皮素和C反应蛋白水平的影响
胆囊切除术,腹腔镜;细胞因子;内皮素;C反应蛋白,,胆囊切除术,腹腔镜;细胞因子;内皮素;C反应蛋白,1资料与方法,2结果,3讨论,参考
【摘要】 目的:探讨开腹与腹腔镜胆囊切除术(LC)2种方法对胆囊疾病患者血中细胞因子、内皮素和C反应蛋白的影响,比较两种方法对机体损伤的程度及安全性。方法:选择行剖腹胆囊切除术(OC)患者50例,LC患者50例,分别于术前和术后抽取静脉血检测IL2、IL6、NK细胞活性、CD4/CD8、内皮素、C反应蛋白含量并进行比较。结果:OC组IL2和NK细胞活性术后较术前下降(P<0.05),IL6术后较术前明显上升(P<0.01)。IL6术后OC组较LC组上升(P<0.05)。OC组IL2术后较LC组降低(P<0.05)。CD4/CD8未发现明显变化。OC组血中内皮素术后含量明显高于LC组患者(P<0.01),C反应蛋白于术后亦高于LC组。结论:研究表明LC损伤小,是一种安全可靠的手术方式。【关键词】 胆囊切除术,腹腔镜;细胞因子;内皮素;C反应蛋白
The influence of laparoscopic cholecystectomy and open cholecystectomy on the level of Cytokines,Endothelin and Creactive protein
WANG Chen,LI Xusheng.
Centre of Laparoscopic Surgery,the Second Hospital of Lanzhou University,Lanzhou 730030,China
【Abstract】 Objective:To research the effect of laparoscopy cholecystectomy (LC) and open cholecystectomy (OC) on the plasma concentration of Cytokines,Endothelin (ET) and Creactive protein (CRP).Methods:The concentration of IL2,IL6,NK cell cytoactive,CD4/CD8,ET and CRP in the blood samples were assessed preand postoperation both laparoscopic (n=50) and open (n=50) cholecystectomy.Results:There was no significant difference in concentration of Cytokines after laparoscopic cholecystectomy. The level of IL6 was strongly increased after open cholecystectomy.But the level of IL2 and NK cell were decreased.IL6's level was increased and IL2's level was decreased in open procedure patients.There was no significant difference in CD4/CD8.Compared with post laparoscopic procedure patients.The level of ET and CRP of group OC were significantly higher than group LC.Conclusions:Laparoscopic cholecystectomy is a safe operation to the patients. ......
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