前列腺素类物质在胃肠道肿瘤发病机制中的作用
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丁岩冰, 肖炜明, 王学浩
前列腺素类物质;环氧化酶;胃肠道肿瘤;分子机制,丁岩冰,肖炜明,王学浩,通讯作者:,Roleofprostaglandinsinpathogenes
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丁岩冰, 肖炜明, 扬州市第一人民医院消化科 江苏省扬州市 225001
王学浩, 南京医科大学第一附属医院肝脏外科 江苏省南京市 210029
通讯作者: 丁岩冰, 225001, 江苏省扬州市, 扬州市第一人民医院消化科. dybchina@sina.vip.com
电话: 0514-7907366
收稿日期: 2006-07-30 接受日期: 2006-10-11
Role of prostaglandins in pathogenesis of gastrointestinal cancer
Yan-Bing Ding, Wei-Ming Xiao, Xue-Hao Wang
Yan-Bing Ding, Wei-Ming Xiao,Department of Gastroenterology, the First People’s Hospital of Yangzhou City, 225001, Jiangsu Province, China
Xue-Hao Wang,Department of Hepatic Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Correspondence to:Yan-Bing Ding, Department of Gastroenterology, Yangzhou First Municipal Hospital, 225001, Jiangsu Province, China, chinadyb@hotmail.com
Received:2006-07-30 Accepted: 2006-10-11
Abstract
There are 2 cyclooxygenase (COX) isoforms commonly referred to COX-1 and COX-2 for the temporal order of their discovery. Although both COX-1 and COX-2 are up-regulated in a variety of circumstances, normally, COX-1 is constitutively expressed in a broad range of cells and tissues. COX-1 expression remains constant under most physiologic or pathologic conditions, and COX-1-derived prostaglandins are considered to play a role in many normal physiologic processes. COX-2, by contrast, is an immediate-early response gene normally absent from most cells but highly inducible in response to inflammatory stimuli, including endotoxin, cytokines, hormones, and tumor promoters. Prostaglandins derived from COX-1 and COX-2 are involved in a variety of physiologic and pathologic processes in the gastrointestinal tract. Recent efforts to identify the molecular mechanisms by which COX-2-derived prostanoids exert their proneoplastic effects have provided a rationale for the possible use of non-steroidal anti-inflammatory drugs alone or in combination with conventional or experimental anticancer agents for the treatment or prevention of gastrointestinal cancers ......
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