通腑颗粒治疗MODS胃肠功能障碍140例
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董 军, 张淑文, 段美丽, 王宝恩, 王 红,
多器官功能不全综合征;胃肠功能障碍;肠屏障功能;通腑颗粒,董军,张淑文,段美丽,王宝恩,王红,阴赪宏,文艳,董军,通讯作者:,Efficacyof
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董军, 北京大学附属临床肿瘤学院ICU 北京市 100036
张淑文, 段美丽, 王宝恩, 王红, 阴赪宏, 文艳, 首都医科大学附属北京友谊医院 北京市 100052
董军, 医师, 主要从事危重症急救方面的研究.
北京市科委重大课题, No. H020920050230
通讯作者: 张淑文, 100052, 首都医科大学附属北京友谊医院感染暨急救内科. zhw401106@sina.com
电话: 010-63138749
收稿日期: 2006-09-19 接受日期: 2006-10-11
Efficacy of Tongfu granules in treatment of grastrointestinal dysfunction in patients with multiple organ dysfunction syndromes: an analysis of 140 cases
Jun Dong, Shu-Wen Zhang, Mei-Li Duan, Bao-En Wang, Hong Wang, Cheng-Hong Yin, Yan Wen
Jun Dong,Department of Intensive Care Unit, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China
Shu-Wen Zhang, Mei-Li Duan, Bao-En Wang, Hong Wang, Cheng-Hong Yin, Yan Wen,Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing 100052, China
Supported bythe Key Project of Beijing Municipal Science and Technology committee, No. H020920050230
Correspondence to:Shu-Wen Zhang, Department of Infectious and Critical Care Medicine, Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing 100052, China. zhw401106@sina.com
Received:2006-09-19 Accepted:2006-10-11
Abstract
AIM: To observe the effect of Tongfu granules on the intestinal dysfunction of patients with multiple organ dysfunction syndromes (MODS).
METHODS: Prospective, multi-center and randomized controlled trial was used in this study. A total of 140 patients selected from the ICU of 10 hospitals in Beijing were randomly divided into group A and B, treated with Mosapride Citrate and Tongfu granules, respectively. The experimental indexes, including peristaltic sound, the condition of pneumatosis and fluid in intestine (performing abdominal B-type ultrasound), serum endotoxin, diamine oxidase (DAO), D-lactic acid were observed at the 0, 48th hour, and the 7th day after treatment (or before death), respectively, and the scores for intestinal dysfunction were compared between the two groups according to Lushan meeting criteria in 1995 ......
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