Von Recklinghausen's Disease and Breast Cancer
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《新英格兰医药杂志》
A 74-year-old woman with a history of von Recklinghausen's disease presented with infiltrating lobular carcinoma of the left breast (T2N0M0 [stage IB], according to the tumor–node–metastasis [TNM] staging system). On physical examination, the patient had innumerable cutaneous neurofibromas (Panels A and B). Of the patient's three children (twin daughters and a son), all had inherited the condition, which is also called neurofibromatosis 1. One of her daughters had died at the age of 12 years from complications of a viral illness, and both her other daughter and her son had died at the age of 38 from cancer. The patient's breast tumor was both estrogen-receptor–positive and progesterone-receptor–positive. She underwent a modified radical mastectomy and was subsequently treated with tamoxifen. During the past three years, there has been no evidence of a recurrence of the tumor, and the patient has had no other complications.
Juan G. Posada, M.D.
Carl G. Chakmakjian, D.O.
Scott and White Memorial Hospital and Clinic
Temple, TX 76508
Juan G. Posada, M.D.
Carl G. Chakmakjian, D.O.
Scott and White Memorial Hospital and Clinic
Temple, TX 76508