LI Zhaoª²Lun1, WANG Yu2, LIANG Xuan3, XUE Wuª²Jun1, TIAN Puª²Xun1

    1Department of Renal Transplantation, 2Department of Hemodiaª²lysis, 3Department of Tumor, First Affiliated Hospital, Medical College, Xi¬ðan Jiaotong University, Xi¬ðan 710061, China

    ¡¾Abstract¡¿ AIM: To compare the effect of lowª²molecular weight heparin with that of lowª²dose heparin on hemodialysis patients at high risk of bleeding. METHODS: Seventyª²six patients at high risk of bleeding were administered with lowª²molecular weight heparin or lowª²dose heparin before hemodialysis. The pressing time after puncturation in the arteriovenous fistulae, different coagulation parameters and blood coagulation in the dialyzer were evaluated in the 2 groups. The changes of proª² and postª²hemodiaª²lysis in platelet counting, thrombin time (TT) and activated partial thromboplastin time (APTT) were investigated. RESULTS: The pressing time after puncturation in the arteriovenous fistulae, the postª²hemodialysis blood coagulation in the dialyzer and the cessation of bleeding in the skin and mucosa were similar in the 2 groups. The cessation time of occult bleeding was shorter in lowª²molecular weight heparin group than that of lowª²dose heparin group after hemodialysis (P<0.05). Compared with proª²hemoª²dialysis, platelet counting was decreased, TT and APTT were slightly prolonged after hemodialysis (P<0.05) in each group, and APTT was prolonged more obviously in lowª²dose heparin group (P<0.01). The postª²hemodialysis coagulation parameters in the lowª²molecular weight heparin group were prior to that of the lowª²dose heparin group (P<0.01), but platelet counting was not. CONCLUSION: Application of lowª²molecular weight heparin is safer than that of lowª²dose heparin in hemodialysis patients at high risk of bleeding. ......